加味芍药甘草汤对僵直少动型帕金森病肝肾阴虚证候的影响观察

Effect of Modified Paeoniae-Glycyrrhizae Decoction on Yin Deficiency Syndrome in Liver and Kidney of Patients with Akinetic-Rigid-Type Parkinson's Disease

目的观察加味芍药甘草汤对僵直少动型帕金森病肝肾阴虚证患者中医证候的影响。方法 60例僵直少动型帕金森病患者随机分为观察组30例和对照组30例。对照组采用单纯美多芭片口服治疗,观察组在对照组治疗基础上给予加味芍药甘草汤口服,2组均连续治疗12周。12周后评价2组患者中医证候评分。结果治疗12周后观察组中医证候疗效总有效率为86.67%,对照组总有效率为33.33%,2组比较差异具有统计学意义(P<0.05)。观察组患者治疗后,肢体拘紧、活动笨拙、言语謇涩、形体消瘦、头晕、耳鸣、失眠多梦、腰膝酸软、小便频数、大便秘结评分均较治疗前明显降低(P<0.05),且与对照组治疗后比较均有统计学意义(P<0.05)。结论加味芍药甘草汤能够明显改善僵直少动型帕金森病肝肾阴虚证的中医证候,明显优于对照组。

Objective:To observe the effect of modified Paeoniae-Glycyrrhiza decoction onTCM symptoms of patients with yin deficiency syndrome in liver and kidney caused by akinetic-rigid-type Parkinson’s disease.Methods:60 patients with akinetic-rigid-type Parkinson’s disease were randomly divided into the treatment group(30 cases)and the control group(30 cases).The control group was orally treated with levodopa and benserazide tablet(Madopar)and the treatment group was additionally given oral modified Paeoniae-Glycyrrhiza decoction while administered with Madopar.Both groups were treated for 12 weeks and TCM symptom scores were evaluated after the 12 weeks.Results:With the 12-week treatment,the effective rate of TCM symptoms with modified Paeoniae-Glycyrrhiza decoction was 86.67%,while the rate of the control group was 33.33%,with statistical difference between the two groups(P<0.05).In detail,adverse signs including stiffness of limbs,clumsy activities,obscure speech,body weight loss,dizziness,tinnitus,insomnia,frequent dreams,weak waist,frequent urination and constipation were mitigated by usage of the decoction in contrast to the control group.Conclusion:Modified Paeoniae-Glycyrrhiza decoction can obviously improve TCM symptoms concerning yin deficiency syndrome in liver and kidney of patients with akinetic-rigid-type Parkinson’s disease and is obviously better than Matopar control group.