短期极低热量饮食干预对住院超重及肥胖患者的疗效及患者依从性

Effect of short-term very low calorie diet on weight of hospitalized patients with obesity and patients' compliance

目的:探讨住院超重及肥胖患者短期进行极低热量饮食干预的效果及其依从性。方法:选择2015年11月至2016年11月在复旦大学附属中山医院内分泌科住院治疗的30例超重及肥胖患者作为研究对象,住院期间给予每日总热量800kcal(1kcal=4.186 8kJ)的饮食干预。比较其入院当日和出院当日的体质量,并观察患者住院期间对极低热量饮食的耐受性,随访患者出院半年内饮食控制和体质量情况。结果:患者平均接受(8±3)d的极低热量饮食干预后,体质量显著下降[(92.86±22.78)kg vs(95.93±23.28)kg,P<0.001]。所有患者均无干预相关严重不良反应;患者住院期间可坚持极低热量饮食治疗,但在出院后长期依从性较差。结论:短期极低热量饮食干预可有效降低超重肥胖患者的体质量,患者耐受性好,但对长期极低热量饮食依从性较差,应加强患者饮食控制。

Objective:To investigate the effect of short-term very low calorie diet(VLCD)on the weight of hospitalized patients with obesity and the patients’compliance.Methods:From November 2015 to November 2016,30 inpatients with obesity or overweight in Zhongshan Hospital received VLCD intervention with total calorie intake of 800 kcal/d(1 kcal=4.186 8 kJ)during hospitalization.The body weight before and after VLCD intervention were compared and the tolerance was observed.After discharge,the diet and weight data were followed up for 6 months.Results:After short-term VLCD intervention for(8±3)d,the body weight decreased from(95.93±23.28)kg to(92.86±22.78)kg(P<0.001).No severe adverse effects were observed.The long-term compliance of patients on VLCD was relatively poor.Conclusions:Short-term VLCD can significantly induce the weight loss in patients with obesity,which is well tolerated.While the long-term compliance on VLCD is relatively poor and should be strengthened in the future.