功能化碳纳米管在肿瘤诊疗领域的研究进展

Advances of functionalized carbon nanotubes in diagnosis and treatment of tumor

碳纳米管以其管状结构所具有的高载药量、易穿透细胞膜等特性成为了许多抗肿瘤药物和基因的优良载体,且随着对碳纳米管研究的逐渐深入,其在肿瘤光热治疗和肿瘤诊断方面的应用也成为了目前的研究热点。然而碳纳米管固有的化学惰性、易聚集等特性限制了其在临床上的应用,为克服其缺陷,研究者通常会先对碳纳米管进行功能化,再对功能化碳纳米管进行一系列的研究。本文对功能化碳纳米管在肿瘤化疗和基因治疗、肿瘤光热治疗以及肿瘤诊断方面的应用进行了总结。

Carbon nanotubes have become a kind of superior antitumor drug and gene carrier due to their special cylindrical structure with high loading capacity and easy penetration into the cell membrane.With the gradual development of researches on carbon nanotubes,their applications in tumor photothermal therapy and diagnosis have also become current research hotspots.However,chemical inertness and aggregation of carbon nanotubes have limited their clinical application.To overcome their drawbacks,researchers would functionalize the carbon nanotubes before further researches.In this article,applications of functionalized carbon nanotubes in cancer chemotherapy and gene therapy,photothermal therapy and cancer diagnosis are summarized.