溶致液晶在经皮及黏膜给药系统研究的策略

Strategies in transdermal and mucosal drug delivery systems: role of lyotropic liquid crystal

溶致液晶是由两亲性分子溶解在极性溶剂中形成的具有特殊几何结构的体系,根据结构的不同,可分为层状液晶、立方相液晶及六角相液晶。近年来,溶致液晶已应用于药物传递领域,尤其是在经皮和黏膜给药系统上表现出独特的优势,如高生物黏附性、高透皮渗透性、低流动性、缓慢释药等。笔者结合所在课题组对溶致液晶在鼻腔给药、经皮给药的研究和相关文献,探讨并分析溶致液晶用于经皮及黏膜给药的技术策略,着重探讨了在鼻腔黏膜给药领域的研究策略,最终为溶致液晶在经皮及黏膜给药制剂的进一步研究提供理论基础和研究方向。

Lyotropic liquid crystal system is formed by the amphiphilic molecules dissolving in polar solvents with a special geometric structure.Lamellar,cubic and hexagonal mesophases are some of the most common lyotropic liquid crystal systems.Recently,they have attracted much research attention because of their distinctive structures and physico-chemical properties(like strong bioadhesion,high permeability,low liquidity,and slow released drug),and have been widely used as carriers for drug delivery systems,especially in transdermal and mucosal fields.According to the research about lyotropic liquid crystal and nasal route of administration in our group,and the related references in recent years,we investigate the technical strategies about the using of lyotropic liquid crystal in transdermal and mucosal drug delivery system.Among them,we specially put the emphasis on the application prospects of lyotropic liquid crystal in the nasal mucosal administration,and then provide a theoretical basis and future research directions in the development of lyotropic liquid crystal in transdermal and mucosal administration fields.