硝呋太尔片联用保妇康栓治疗妊娠期阴道炎的疗效

Efficacy of nifuratel tablets combined with Baofukang suppository in treatment of vaginitis in pregnant women

目的:观察硝呋太尔片口服联用保妇康栓外用治疗妊娠期阴道炎的临床疗效,为临床治疗提供参考。方法:255例妊娠期合并阴道炎病人随机分为硝呋太尔组、保妇康栓组和联合用药组,每组各85例。硝呋太尔组病人用硝呋太尔片0.2g,po,tid;保妇康栓组病人阴道内给予保妇康栓1枚,qn;联合用药组病人用(硝呋太尔片0.2g,po,qd+保妇康栓1枚,qn)。治疗7d,比较3组病人临床总有效率、临床症状消失时间、复发率及相关药品不良反应(ADRs)。结果:硝呋太尔组、保妇康栓组和联合用药组的临床总有效率分别为72.94%、76.47%和92.94%;临床症状、体征消失时间分别为(5.9±1.6)、(5.6±1.3)和(3.5±1.2)d;复发率分别为16.13%、21.54%和3.80%。硝呋太尔组与保妇康栓组比较,差异无统计学意义(P>0.05);联合用药组与硝呋太尔和保妇康栓单用组比较,有效率高、症状体征消失时间短、复发率低,差异均存在统计学意义(P<0.05)。3组病人均未见严重ADRs,ADRs发生率差异无统计学意义(P>0.05)。结论:对于妊娠期合并阴道炎病人采用硝呋太尔口服联用保妇康栓外用治疗,能显著提高临床疗效,缩短治疗时间,降低复发率,且安全性好,值得临床推广。

Objective:To observe efficacy of nifuratel tablets combined with Baofukang suppository in treatment of vagini-tis in pregnant women,so as to provide reference for clinical treatment of the disease.Methods:A total of 255 pregnant women with vaginitis were randomly divided into the nifuratel,Baofukang and nifuratel plus Baofukang groups,each consisting of 85 patients.The patients in the nifuratel group received nifuratel tablets at a dosage of 0.2 g three times a day,the patients in the Baofukang group were given 1 Baofukang suppository by vagina every night,and the patients in the nifuratel plus Baofukang group were treated with nifuratel tablets at the same dosage and 1 Baofukang suppository by vagina.After 7 days of treatment,total clinical efficacy,symptom eradication time,recurrent rate and adverse drug reactions(ADRs)were compared between the patients of the 3 groups.Results:Total clinical effective rates for the nifuratel,Baofukang and nifuratel plus Baofukang groups were 72.94%,76.47%and 92.94%,respectively.The eradication time of clinical symptoms were(5.9士1.6),(5.6士1.3)and(3.5士1.2)days respectively,and the recurrent rates were 16.13%,21.54%and 3.80%.There was no statistical signif-icance,when comparisons were made between the nifuratel group and the Baofukang group(P〉0.05).As compared with the nifuratel group and the Baofukang group,the combined group showed the features of high efficacy,short time of symptom dis-appearance and low recurrence,and statistical significance could be noted(PC0.05).Serious ADRs were not present in all the patients of the 3 groups,and statistical significance was not found in the incidence of ADRs,when comparisons were made be-tween the 3 groups(P〉0.05).Conclusion:For patients with pregnancy combined with vaginitis,treatment with nifuratel plus Baofukang suppository could significantly increase clinical efficacy,shorten treatment time,reduce recurrence with good safety.For this reason,it was worth further clinical promotion.