摘要
目的:观察康复新液联合重组人表皮生长因子(rhEGF)外用溶液(Ⅰ)对儿童口腔黏液囊肿治疗后创面的疗效。方法:196例口腔黏液囊肿患儿随机分为对照组和治疗组,每组98例。均先用多功能电离子手术治疗仪进行黏液囊肿治疗,清洁创面后,对照组用碘甘油涂抹创面,tid;治疗组用康复新液含漱或湿敷创面,tid,并用rhEGF外用溶液(Ⅰ)喷洒于创面上,qd。比较两组患儿创面愈合时间、疼痛时间、疼痛程度、治疗7d创面愈合有效率和术后6个月内的复发率。结果:治疗组患儿创面愈合时间和疼痛时间明显短于对照组[创面愈合时间:(8.02±0.79)d vs(9.01±0.75)d,P<0.05;疼痛时间:(2.12±0.15)d vs(2.98±0.19)d,P<0.01];治疗组患儿的疼痛分数为10(8~18)分[中位数(Q1~Q3)];明显低于对照组的21(14~27)分(P<0.01);用药7d创面愈合有效率治疗组明显高于对照组(96.9%vs 86.8%,P<0.05);治疗组复发例数少于对照组,但差异无显著意义(P>0.05)。结论:康复新液联合rhEGF外用溶液(Ⅰ)可有效促进儿童口腔黏液囊肿治疗后创面的愈合,缩短愈合时间,提高患者对创面愈合满意度。
Objective:To observe the clinical effects of Kangfuxin liquid combined with recombinant human epidermal growth factor(rhEGF)derivative for external use on the wound surface after treatment of oral mucocele in children.Methods:196 child patients with oral mucocele were randomly divided into the control and treatment groups,with 98 patients in each group.First,the oral mucocele of all the patients were treated with a multi-purpose electric ion operating apparatus.In the control group,the wound surface after cleaning was treated with iodine glycerol,thrice a day.In the treatment group,the wound surface after cleaning were gargled or applied with wet dressing of Kangfuxin liquid,thrice a day,and rhEGF derivative for external use,liquid was sprayed on the wound surface,once a day.Wound healing time,pain time,pain severeness and effective rate of wound healing 7 days after treatment with the drugs were compared between the two groups.Results:The wound healing time and pain time in the treatment group were significantly shorter than those in the control group[wound heal-ing time:(8.02士0.79)d vs(9.01士0.75)d,P<0.05;pain time:(2.12士0.15)d vs(2.98士0.19)d,P<0.01],and the pain scores in the treatment group were 10(8-18)[median(Q1-Q3)],which were significantly lower than those in the control group[21(14-27),P<0.01].The effective rate of wound healing 7 days after treatment in the treatment group was significantly higher than that in the control group(96.9%vs 86.8%,P<0.05).The relaps number in the treatment group was more than that in the control group,but the difference was not significant(P〉0.05).Conclusion:Kangfuxin liquid combined with rhEGF derivative for external use can effectively promote healing of wounds,shorten healing time and improve patient satisfaction with wound healing.
作者
唐金玲
何谢玲
汤建萍
李智慧
TANG JinLing;HE XieLing;TANG JianPing;LI ZhiHui(Department of Dermatology,Hunan Children's Hospital,Changsha 410007,China)
出处
《药学服务与研究》
CAS
2018年第2期130-133,共4页
Pharmaceutical Care and Research