康复新液联合重组人表皮生长因子外用溶液(Ⅰ)对儿童口腔黏液囊肿治疗后创面的影响

Effects of Kangfuxin liquid combined with recombinant human epidermal growth factor derivative for external use on the wound surface after treatment of oral mucocele in children

目的:观察康复新液联合重组人表皮生长因子(rhEGF)外用溶液(Ⅰ)对儿童口腔黏液囊肿治疗后创面的疗效。方法:196例口腔黏液囊肿患儿随机分为对照组和治疗组,每组98例。均先用多功能电离子手术治疗仪进行黏液囊肿治疗,清洁创面后,对照组用碘甘油涂抹创面,tid;治疗组用康复新液含漱或湿敷创面,tid,并用rhEGF外用溶液(Ⅰ)喷洒于创面上,qd。比较两组患儿创面愈合时间、疼痛时间、疼痛程度、治疗7d创面愈合有效率和术后6个月内的复发率。结果:治疗组患儿创面愈合时间和疼痛时间明显短于对照组[创面愈合时间:(8.02±0.79)d vs(9.01±0.75)d,P<0.05;疼痛时间:(2.12±0.15)d vs(2.98±0.19)d,P<0.01];治疗组患儿的疼痛分数为10(8~18)分[中位数(Q1~Q3)];明显低于对照组的21(14~27)分(P<0.01);用药7d创面愈合有效率治疗组明显高于对照组(96.9%vs 86.8%,P<0.05);治疗组复发例数少于对照组,但差异无显著意义(P>0.05)。结论:康复新液联合rhEGF外用溶液(Ⅰ)可有效促进儿童口腔黏液囊肿治疗后创面的愈合,缩短愈合时间,提高患者对创面愈合满意度。

Objective:To observe the clinical effects of Kangfuxin liquid combined with recombinant human epidermal growth factor(rhEGF)derivative for external use on the wound surface after treatment of oral mucocele in children.Methods:196 child patients with oral mucocele were randomly divided into the control and treatment groups,with 98 patients in each group.First,the oral mucocele of all the patients were treated with a multi-purpose electric ion operating apparatus.In the control group,the wound surface after cleaning was treated with iodine glycerol,thrice a day.In the treatment group,the wound surface after cleaning were gargled or applied with wet dressing of Kangfuxin liquid,thrice a day,and rhEGF derivative for external use,liquid was sprayed on the wound surface,once a day.Wound healing time,pain time,pain severeness and effective rate of wound healing 7 days after treatment with the drugs were compared between the two groups.Results:The wound healing time and pain time in the treatment group were significantly shorter than those in the control group[wound heal-ing time:(8.02士0.79)d vs(9.01士0.75)d,P<0.05;pain time:(2.12士0.15)d vs(2.98士0.19)d,P<0.01],and the pain scores in the treatment group were 10(8-18)[median(Q1-Q3)],which were significantly lower than those in the control group[21(14-27),P<0.01].The effective rate of wound healing 7 days after treatment in the treatment group was significantly higher than that in the control group(96.9%vs 86.8%,P<0.05).The relaps number in the treatment group was more than that in the control group,but the difference was not significant(P〉0.05).Conclusion:Kangfuxin liquid combined with rhEGF derivative for external use can effectively promote healing of wounds,shorten healing time and improve patient satisfaction with wound healing.