不同专业医务人员对药品不良反应关联性评价结果的比较

Comparisons of adverse drug reactions relevance evaluated by different professional medical personnel

目的:了解南京大学医学院附属鼓楼医院不同专业医务人员对药品不良反应(ADRs)关联性评价的正确性,为深入开展ADRs监测工作提供参考。方法:由2名从事ADRs监测的专职人员对本院2016年上报的680份ADRs报告,按照国家ADRs监测中心制定的关联性评价标准进行重新评价,比较不同专业医务人员对ADRs关联性和严重ADRs关联性评价结果的正确性。结果:680份ADRs报告中,来自护士、医师和药师的比例分别为43.82%和41.03%和15.15%;关联性评价结果主要集中在"可能"和"很可能",占比94.12%,护士、医师和药师ADRs关联性评价的正确率分别为60.40%、65.95%和85.44%。其中严重ADRs报告52例,护士、医师和药师ADRs关联性评价的正确率分别为62.50%、64.71%和85.19%;工作年限<3年、3~5年和>5年的药师ADRs关联性评价的正确率分别为82.61%、89.47%和95.55%。结论:药师对ADRs关联性评价正确率高于护士和医师。

Objective:To investigate the accuracy of adverse drug reactions relevance evaluation(AADRRE)by different professional medical personnel of the Drum Tower Hospital Affiliated to Medical College of Nanjing University,so as to pro-vide reference for further implementation of ADRs monitoring.Methods:Six hundred and eighty ADRs reports submitted by the hospital administration in 2016 were reevaluated by 2 medical professionals who were fully engaged in ADRs monitoring in accordance with the relevance evaluation criteria by the National Center of ADR Monitoring,and then,the accuracy of the eval-uation results concerning ADR relevance and serious ADR relevance by different medical personnel was compared in the study.Results:In the 680 ADRs reports,the proportions of the reports from nurses,physicians and pharmacists accounted for 43.82%,41.03%and 15.15%,respectively.The results of relevance evaluation mainly concentrated on“likely”and“very likely'',which accounted for 94.12%.The accuracy percentages of the AADRRE by nurses,physicians and pharmacists ac-counted for 60.40%,65.95%and 85.4机'respectively.In the 52 serious ADRs reports,the AADRRE by nurses,physicians and pharmacists accounted for 62.50%,64.71%and 85.19%,respectively.The evaluation accuracy of the pharmacists with length of service shorter than 3 years/3-5 years and longer than 5 years was 82.61%,89.47%and 95.55%,respectively.Conclusion:The evaluation accuracy of the pharmacists was higher than those of the nurses and physicians.