酸奶对慢性肾功能衰竭辅助治疗作用的研究

Study on the therapeutic effect of yoghurt on chronic renal failure

研究了酸奶配合药物作用对腺嘌呤所致大鼠慢性肾功能衰竭的影响效果。采用腺嘌呤复制慢性肾功能衰竭大鼠模型,以酸奶配合药物作为受试物进行灌胃,通过检测大鼠体质量、血肌酐(Scr)、尿素氮(BUN)、一氧化氮(NO)、超氧化物歧化酶(SOD)、血清总蛋白(TP)、钙(Ca)、磷(P)、24 h尿量、尿蛋白(UP)及肾脏病理组织学变化,分析酸奶对慢性肾功能衰竭大鼠的辅助治疗效果。试验结果表明,酸奶配合药物使用可显著降低大鼠Scr、BUN水平,减缓UP,调节Ca、P的含量,提高SOD、TP水平,具有保护肾功能的作用。酸奶配合药物共同作用可对慢性肾功能衰竭大鼠的病情起到缓解作用。

Purpose:to study yogurt used together with medicaments on the impact of chornic renal failure rats induced by adenine.Method:by using the model of chornic renal failure rats duplicated by adenine,the body weight of rats,serum creatinine(Scr),urea nitrogen(BUN),nitric oxide(NO),superoxide dismutase(SOD),total serum protein(TP),calcium(Ca),phosphorus(P),urine volume after 24 hours,urine protein(UP)were detected to compare the influence of the to study yogurt used together with medicaments and to improvement of the chornic renal failure.Conclusion:to study yogurt used together with medicaments can improve the chornic renal failure and play a part in protection of the kidney.