氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果

Clinical effect of Amlodipine Besylate and Atorvastatin Calcium Tablets in treatment of hypertension complicated with coronary heart disease

目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果。方法选取2015年8月~2017年3月我院收治的80例高血压合并冠心病患者作为研究对象,根据随机数字表法将其分为两组,每组各40例。对照组患者接受阿托伐他汀钙片治疗,研究组患者接受氨氯地平阿托伐他汀钙片治疗。比较两组患者的治疗效果以及治疗前后的血压、血脂、炎性因子水平变化情况。结果研究组患者的治疗总有效率(92.50%)高于对照组(77.50%),差异有统计学意义(P<0.05)。治疗前,两组患者的SBP、DBP、HDL-C、LDL-C、TG、TC、ET、NO、v WF、TNF-α、IL-6、CRP比较,差异无统计学意义(P>0.05);治疗后,两组患者的HDL-C、ET指标比较,差异无统计学意义(P>0.05),但研究组患者的SBP、DBP、LDL-C、TG、TC、v WF、TNF-α、IL-6、CRP均低于对照组,NO高于对照组,差异有统计学意义(P<0.05)。结论高血压合并冠心病采用氨氯地平阿托伐他汀钙片治疗,可明显改善患者的血压、心率等指标,缓解疾病症状,且疗效突出,能够达到改善生活质量的目的 ,值得应用推广。

Objective To investigate the clinical effect of Amlodipine Besylate and Atorvastatin Calcium Tablets in treatment of hypertension complicated with coronary heart disease.Methods A total of 80 patients with hypertension complicated with coronary heart disease who treated in our hospital from August 2015 to March 2017 were selected as subjects,and were divided into two groups according to the random digital table method,with 40 cases in each group.The control group were received the Atorvastatin Calcium Tablets treatment,while the study group were received Amlodipine Besylate and Atorvastatin Calcium Tablets treatment.The therapeutic effect,blood pressure,blood lipid and inflammatory factors before and after treatment of the two groups were compared.Results The total effective rate of the patients in the study group(92.50%)was higher than that in the control group(77.50%),and the difference was statistically significant(P<0.05).Before treatment,the SBP,DBP,HDL-C,LDL-C,TG,TC,ET,NO,vWF,TNF-α,IL-6 and CRP in the two groups were compared,and the differences were not statistically significant(P>0.05).After treatment,the HDL-C and ET of the two groups were compared,and the differences were not statistically significant(P>0.05),while the SBP,DBP,LDL-C,TG,TC,vWF,TNF-α,IL-6 and CRP in the study group were both lower than those in the control group,the NO was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The Amlodipine Besylate and Atorvastatin Calcium Tablets in treatment of hypertension complicated with coronary heart disease which can significantly improve the blood pressure,heart rate and other indicators,and can relieve the symptoms of the disease,and the clinical effect are outstanding,to achieve the purpose of improving the quality of life,thus it is worth of application and promotion.