参附注射液对严重创伤患者免疫功能及病情预后的影响

Effect of Shenfu Injection on immune function and prognosis of patients with severe trauma

目的探讨参附注射液治疗严重创伤患者效果及对免疫功能、病情预后的影响。方法选取2016年1月~2017年6月因严重创伤于我院治疗的80例患者作为研究对象,依据随机数字表法将其分为两组,每组各40例。对照组患者采用常规治疗,观察组患者联合参附注射液进行治疗,7 d为1个疗程。比较两组患者的免疫功能指标(NK细胞、CD4^+/CD8^+、CD3^+)改善情况,比较两组患者的病死率及多器官功能障碍综合征(MODS)发生率。结果治疗后,观察组患者的NK细胞、CD4^+/CD8^+、CD3^+水平高于治疗前,差异有统计学意义(P<0.05)。治疗后,观察组患者的NK细胞、CD4^+/CD8^+、CD3^+水平高于对照组,差异有统计学意义(P<0.05)。观察组患者的MODS发生率是10.00%(4/40),病死率是5.00%(2/40),对照组患者的MODS发生率是35.00%(14/40),病死率是22.50%(9/40),观察组患者的MODS发生率及病死率均高于对照组,差异有统计学意义(P<0.05)。结论对严重创伤患者而言,早期应用参附注射液进行治疗具有重要意义,可有效改善患者的免疫功能,改善预后,值得推广。

Objective To investigate the effect of Shenfu Injection on the patients with severe trauma and the effect on the immune function and the prognosis of the patients.Methods A total of 80 patients with severe trauma treated in our hospital from January 2016 to June 2017 were selected as subjects and randomly divided into the control group and the control group according to the random digital table method,40 cases in each group.The control group was treated by conventional treatment,and the observation group was treated with Shenfu Injection for 7 days as one course of treatment.The two groups of immune functions indexes(NK cells,CD4+/CD8+,CD3+)were compared,and the mortality of the two groups and the incidence of multiple organ dysfunction syndrome(MODS)were compared.Results After treatment,the observation group of NK cells,CD4+/CD8+and CD3+were higher than those before treatment,the differences were statistically significant(P<0.05).The observation group of NK cells,CD4+/CD8+,CD3+levels were higher than those of the control group after treatment,the differences were statistically significant(P<0.05).The incidence of MODS in the observation group was 10.00%(4/40)and the mortality rate was 5.00%(2/40),the incidences of MODS in the control group was 35.00%(14/40)and the mortality rate was 22.50%(9/40),the incidence of MODS and mortality in the observation group were both higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The early application of Shenfu Injection for patients with severe trauma is of great significance.It can effectively improve the immune function and improve the prognosis.It is worth popularizing.