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脂肪性肝炎对于非酒精性脂肪性肝病预后判断仍很重要 被引量:3

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摘要 非酒精性脂肪性肝病(NAFLD)是一种与遗传易感和胰岛素抵抗密切相关的慢性代谢应激性肝病,疾病谱包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)及其相关肝硬化[1-4]。随着肥胖、糖尿病和代谢综合征的流行,NAFLD已成为全球第一大慢性肝脏疾病,与失代偿期肝硬化、肝功能衰竭、肝细胞癌的高发密切相关[1-4]。尽管此前医学界花了10余年时间才认识到丙型肝炎病毒(HCV)感染是终末期肝病的重要原因,现在我们同样经历了漫长时间才逐渐意识到NASH的巨大危害,2020年NASH即将成为美国肝脏移植手术的首要原因[5]。
出处 《肝脏》 2018年第4期285-287,共3页 Chinese Hepatology
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  • 1Xiao-Yan Duan, Liang Qiao and Jian-Gao Fan Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China ,Storr Liver Unit at the Westmead Millennium Institute, the University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia.Clinical features of nonalcoholic fatty liver disease-associated hepatocellular carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2012,11(1):18-27. 被引量:16
  • 2Yan Qian and Jian-Gao Fan Shanghai, China Center for Fatty Liver Disease, First People’ s Hospi- tal , Shanghai Jiaotong University, Shanghai 200080, China.Obesity, fatty liver and liver cancer[J].Hepatobiliary & Pancreatic Diseases International,2005,4(2):173-177. 被引量:11
  • 3European Assiation for the Study of the Liver,European Association for the Study of Diabetes,European Association for the Study of Obesity. Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol, 2016,Epub[ahead of print].
  • 4Bedossa P,FLIP Pathology Consortium. Utility and appropriate- ness of the fatty liver inhibition of progression (FLIP) algo- rithm and steatosis,activity,and fibrosis (SAF) score in the e- valuation of biopsies of nonalcoholic fatty liver disease. Hepa- tology, 2014,60( 2 ):565-575.
  • 5Ratziu V,Bellentani S,Cortez-Pinto H,et al. A position state- ment on NAFLD/NASH based on the EASL 2009 special con- ference. J Hepatol,2010,53(2):372-384.

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