等离子射频消融术对慢性肥厚性鼻炎患者疗效及鼻腔分泌物NO、CRP水平的影响

The efficacy and influence of plasma radiofrequency on the levels of nasal secretions NO and CRP of patients with chronic hypertrophic rhinitis

目的探讨等离子射频消融术对慢性肥厚性鼻炎患者疗效及鼻腔分泌物一氧化氮(NO)、C-反应蛋白(CRP)水平的影响。方法耳鼻喉科住院部慢性肥厚性鼻炎患者112例,采用随机数字表法将患者分为观察组和对照组,每组56例。对照组患者采用常规下鼻甲部分切除术治疗,观察组患者采用等离子射频消融术治疗。采用酶联免疫吸附法(ELISA)检测鼻腔分泌物NO、CRP水平,观察2组疗效,术前、术后1、3个月鼻塞症状主观感觉评分、视觉模拟量表(VAS)和鼻腔间隙。结果观察组治疗总有效率明显高于对照组(P<0.05)。术前,2组鼻塞症状主观感觉、VAS评分与鼻腔间隙比较差异无统计学意义(P>0.05),手术后1、3个月,全部患者鼻塞症状主观感觉VAS评分明显低于治疗前,鼻腔间隙明显大于治疗前(P<0.05),其中观察组鼻塞症状主观感觉VAS评分明显低于对照组,鼻腔间隙明显大于对照组(P<0.05)。观察组手术时间与水肿时间明显短于对照组,术中出血量明显少于对照组,鼻腔分泌物NO、CRP水平明显低于对照组,并发症发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论等离子射频消融术治疗慢性肥厚性鼻炎患者疗效满意,可明显缓解鼻腔分泌物NO、CRP水平增高导致的术后反应程度,促进机体恢复,值得临床推广应用。

Objective To investigate the influence of plasma radiofrequency on the levels of nasal secretions nitric oxide(NO)and C-reactive protein(CRP)and its clinical efficacy in patients with chronic hypertrophic rhinitis.Methods A total of 112 patients with chronic hypertrophic rhinitis who were admitted and treated in our hospital from January 2015 to January 2016 were enrolled in the study.The patients were divided into two observation group and control group groups according to random number table,with 56 patients in each group.The patients in control group were treated by routine inferior turbinate partial resection,however,the patients in observation group were treated by plasma radiofrequency ablation.The levels of NO and CRP in nasal secretions were detected by enzyme-linked immunosorbent assay(ELISA).The clinical efficacy,the subjective feeling scores of the rhinobyon symptom before operation and at 1m,3m after operation,the visual analogue scale(VAS)scores and nasal cavity gap were observed and compared between two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There were no statistically significantly differences in the subjective feeling scores of rhinobyon symptom,VAS scores and the nasal cavity gap of patients before surgery between the two groups(P>0.05).The subjective feeling scores of rhinobyon symptom,VAS scores at 1m,3m after operation were significantly lower than those before operation in both groups(P<0.05),moreover,the nasal cavity gap of patients at 1m,3m after operation was greater than that before operation(P<0.05).The subjective feeling scores of rhinobyon symptom,VAS scores in observation group were significantly lower than those in control group(P<0.05),and the nasal cavity gap of patients in observation group was significantly greater than that in control group(P<0.05).The lengths of operation and edema in observation group were significantly shorter than those in control group(P<0.05).The amount of intraoperative bleeding,the levels of NO and CRP in nasal secretions and incidebce rate of complications in obsereve group were significantly lower than those in control group(P<0.05).Conclusion The curative effects of the plasma radiofrequency ablation on chronic hypertrophic rhinitis are satisfactory.The plasma radiofrequency ablation can obviously relieve the postoperative reaction degree caused by increase of the levels of NO and CRP levels in nasal secretions,and promote body’s recovery,therefor,which is worth using widely in clinical practice.