双歧杆菌四联活菌片治疗老年慢性功能性便秘临床观察

Clinical Observation of Bifidobacterium Tetravaccine Tablets(Live) in Treatment of Elderly Patients with Chronic Functional Constipation

目的探讨双歧杆菌四联活菌片治疗老年慢性功能性便秘的临床疗效。方法选择2015年10月—2016年5月3家医院就诊的老年慢性功能性便秘174例,按治疗方法分为试验组91例和对照组83例,试验组给予双歧杆菌四联活菌片,对照组给予莫沙必利片治疗。2组疗程均为4周。比较2组临床疗效、Wexner便秘评分及不良反应发生情况。结果试验组总有效率高于对照组(P<0.05)。治疗4周后试验组Wexner便秘评分低于对照组(P<0.05)。2组均未发生严重不良反应。结论双歧杆菌四联活菌片治疗老年慢性功能性便秘效果较好且安全性较高。

Objective To investigate therapeutic effect of Bifidobacterium Tetravaccine Tablets(Live)in treatment of elderly patients with chronic functional constipation.Methods A total of 174 elderly patients with chronic functional constipation,who were treated in three hospitals during October 2015 and May 2016,were divided into experimental group(n=91)and control group(n=83).Experimental group was treated with Bifidobacterium Tetravaccine Tablets(Live),while control group was treated with Mosapride Tablets.All patients were treated for 4 weeks.Clinical efficacy,Wexner constipation score and incidence rate of adverse reactions were compared in two groups.Results The total effective rate in experimental group was significantly higher than that in control group(P<0.05).After 4 weeks of treatment,Wexner constipation score in experimental group was significantly lower than that in control group(P<0.05).No seriously adverse reactions were found in two groups.Conclusion Bifidobacterium Tetravaccine Tablets(Live)in treatment of elderly patients with chronic functional constipation may achieve good effectiveness and safety.