胶质母细胞瘤中微RNA的功能及临床价值的研究进展

Research Progress of Function and Clinical Value of MicroRNA in Glioblastoma

胶质母细胞瘤(GBM)是恶性度最高的神经系统肿瘤之一,患者常在发病后短期内病死。GBM的致病机制十分复杂,目前临床上尚无有效的治疗方法。现有的研究数据显示,大量微RNA(miRNA)通过特定的信号通路参与对GBM发生、发展过程的调控。同时,作为无创生物学指标,miRNA在用于GBM诊断及预后评估中有重要的临床价值。靶向miRNA治疗GBM的研究仍仅停留在细胞及动物模型阶段,虽然基础研究显示出了较好的疗效,但是距离临床应用还有一定距离。

Glioblastoma(GBM)is one of the most malignant neural tumors,and patients with GBM often die soon after the onset.The pathogenesis of GBM is very complicated,and there is no effective treatment for GBM.The current research results show that a variety of microRNA(miRNA)are involved in the regulation of GBM occurrence and development through specific signal pathways.Meanwhile,as a non-invasive biological indicator,there is an important clinical value of miRNA in the diagnosis and prognosis of GBM.The research of targeted miRNA treatment for GBM is still in the cell and animal model stage,although the basic research shows a good result,there is still a certain distance to the clinical application.