矮小症儿童IGF-1水平与心外膜脂肪组织厚度相关性研究

Association between IGF-1 level and epicardial adipose tissue thickness in children with growth hormone deficiency

目的观察矮小症儿童胰岛素样生长因子(insulin-like growth factor-1,IGF-1)水平与心外膜脂肪组织(epicardial adipose tissue,EAT)厚度的相关性。方法应用队列研究方法,收集2017年1月至2017年10月在济宁医学院附属医院住院的青春期前矮小症患者32例,按照生长激素(growth hormone,GH)激发试验结果,以生长激素峰值(GHmax)5ng/ml为切点,将患者分为两组。A组:11例,GHmax<5ng/ml;B组:21例,GHmax≥5ng/ml。应用超声心动图测得每例患者EAT厚度,同时收集患者的一般资料及血脂、GH、IGF-1、骨龄(bone age,BA)等采用易侕软件进行分析比较。结果 A组EAT厚度较B组增加(P<0.05);IGF-1SDS与EAT厚度呈负向关系(β=-0.486,95%CI:-0.849^-0.122,P=0.015),而B组无明显相关(β=0.020,95%CI:-0.259~0.299,P=0.887)。结论完全生长激素缺乏症儿童IGF-1SDS水平与EAT厚度呈显著负相关。

Objective To observe the change of epicardial adipose tissue(EAT)thickness in children with growth hormone deficiency.Methods The cohort study method was used.32 prepuberty children diagnosed with short stature were collected in Affiliated Hospital of Jining Medical University from January to October in 2017.According to the growth hormone stimulation test results,all patients were divided into two groups,(group A:n=11,GHmax<5ng/ml;group B:n=21,GHmax≥5ng/ml).Everyone’s EAT thickness was tested by echocardiography,while general information and related results were collected such as blood lipid,growth hormone,insulin-like growth factor-1(IGF-1)and bone age etc.All data were analysed by EmpowerStats.Results EAT thickness was thicker in group A compared with group B(P<0.05),and there was significant inverse correlation between IGF-1SDS and EAT thickness in group A(β=-0.486,95%CI:-0.849^-0.122,P=0.015),but there is no correlation in group B(β=0.020,95%CI:-0.259~0.299,P=0.887).Conclusion The epicardial thickness in children with growth hormone deficiency was higher than that in the control group,which was negatively correlated with IGF-1SDS.