维生素D与多囊卵巢综合征的相关研究进展

Research Progress in the Correlation between Vitamin D and Polycystic Ovary Syndrome

多囊卵巢综合征(PCOS)是育龄妇女常患的一种生殖内分泌疾病,往往与胰岛素抵抗、高胰岛素血症及血脂紊乱等代谢紊乱相关。PCOS患者糖尿病、高血压、心血管疾病、子宫内膜癌等的发病率增加,严重影响女性的健康。大部分研究认为PCOS患者存在维生素D缺乏,维生素D水平与PCOS患者的临床特征和代谢紊乱存在相关性,维生素D受体基因多态性可能在其中起重要作用。补充维生素D可能有利于PCOS患者的症状及代谢紊乱的改善,但具体结果还需进一步研究。

Polycystic ovary syndrome(PCOS)is a common reproductive endocrine disease in fertile women,which is often associated with metabolic disorders,insulin resistance and hyperinsulinemia.The morbidity of diabetes,hypertension,cardiovascular disease and endometrial cancer increases in patients with PCOS,which seriously threats the women′s survival and health.Most researchers put forward that most PCOS patients suffer from vitamin D deficiency.Vitamin D levels may be associated with the clinical features and metabolic disorders in PCOS patients,and vitamin D receptor genetic polymorphism may play an important role.Vitamin D supplementation may be beneficial in improving of symptoms and metabolic disorders in PCOS patients,but the specific results need to be further studied.