中性粒细胞胞外诱捕网的作用机制及其在多种疾病中作用的研究进展

Mechanism of neutrophil extracellular traps and research progress of its role in various diseases

中性粒细胞胞外诱捕网(NETs)是中性粒细胞发挥生物学作用的另一种表现形式。除了具有强大的抗感染作用以外,它亦对机体产生直接或者间接的损伤,可与炎症因子相比拟。近年来研究表明NETs在抗炎、血栓形成、自身抗体的产生等方面均有参与。本文就NETs的基本组成结构以及在多种疾病发生、发展中的作用作一综述。

Neutrophil extracellular traps(NETs)is another form of neutrophil playing biological role.In addition to its strong anti-infective effect,NETs has direct or indirect injury on body,which can be compared to those of inflammatory factors.In recent years,studies suggested that NETs has involved in anti-inflammation,thrombosis and autoantibody production etc.The present article made a review on basic composition and structure of NETs and its role in occurrence and development of various diseases.