MicroRNAs对血管损伤后的再狭窄和血栓形成的抑制

Inhibition of microRNAs on restenosis and thrombosis after vascular injury

经皮冠脉介入治疗术(PCI)术后可能会发生再狭窄和支架内血栓形成,其如何抑制以改善预后,是个很大的挑战。MicroRNA的发现为此开拓了新视野,可通过调节microRNA来抑制再狭窄和支架内血栓形成。本文总结了microRNA在血管损伤后发挥作用的实验和临床证据,提示循环中的microRNA可作为抑制PCI术后再狭窄的生物标志物。

Restenosis and in-stent thrombosis may occur after percutaneous coronary intervention(PCI),therefore,its inhibition and improvement of patient's prognosis is a big challenge.Discovery of microRNAs develops a new view for this.Restenosis and in-stent thrombosis may be inhibited through regulating microRNA.The present article summarized experimental and clinical evidence of microRNA playing role after vascular injury,suggest that circulating microRNA can be used as a biomarker for inhibiting restenosis after PCI.