赖氨匹林治疗小儿高热疗效的Meta分析

The meta-analysis on efficacy of aspisol in treating high fever in children

目的系统评价赖氨匹林治疗小儿高热的疗效。方法检索维普(VIP)、中国知网(CNKI)、万方等数据库,检索时间建库至2016年,纳入赖氨匹林治疗(试验组)与复方氨林巴比妥(安痛定)(对照组)治疗小儿高热的随机对照试验(RCTs),独立评价纳入研究的质量并提取资料,采用Rev Man 5.3软件进行统计分析。结果共纳入9篇RCTs,包含患者3 659例,Meta分析结果显示:试验组用赖氨匹林治疗小儿高热,用药1 h后体温明显低于对照组(肌肉注射安痛定),差异有统计学意义[MD=-0.73,95%CI(-1.03,-0.44),P<0.01];用赖氨匹林治疗小儿高热,用药1 h有效率明显高于对照组,差异有统计学意义[RR=1.16,95%CI(1.07,1.27),P<0.01];用药1 h后显效率显著高于对照组,差异有统计学意义[RR=1.55,95%CI(1.35,1.79),P<0.01]。结论肌肉注射赖氨匹林治疗小儿高热疗效比肌肉注射安痛定效果显著。

Objective To systematically evaluate the efficacy of aspisol in the treatment of high fever in children.Methods Searching for CNKI,Wanfang,VIP database,we read the literatures on the efficacy and safety of aspisol in the treatment of high fever in children which published since database to now.Their randomized controlled trials(RCTs)were collected,the quality evaluation was performed and the data was analyzed by using RevMan5.3 software.Results Nine RCTs were included,involving 3 659 patients.The result of meta-analysis showed as follows:aspisol group could obviously reduce the temperature an hour later[MD=-0.73,95%CI(-1.03,0.44),P<0.01],Aspisol group had obviously higher effective rate of medication an hour later[RR=1.16,95%CI(1.07,1.27),P<0.01]and the significant improvement rate of medication an hour later[RR=1.55,95%CI(1.35,1.79),P<0.01]than antondine injection group.Conclusion Aspisol is more effective for high fever in children than Antondine injection.