针刺治疗卒中后轻度认知障碍临床观察

Clinical observation of acupuncture treatment of mild cognitive impairment after stroke

目的分析栝楼桂枝汤联合针刺治疗卒中后轻度认知障碍临床疗效情况。方法选取2015年5月至2017年5月间在本院接受治疗的卒中后轻度认知障碍患者115例,依据随机数字表法将患者分为2组,观察组(58例)进行针刺和栝楼桂枝汤治疗,对照组(57例)服用栝楼桂枝汤;观察患者临床疗效、不良反应状况,简明精神状态(MMSE)评分、神经能力受损(NIHSS)评分和日常生活的活动能力评分(ADL)状况,检测其血清同型半胱氨酸(HCY)、胆固醇(TC)、纤维蛋白原(FIB)和甘油三脂(TG)含量改变状况。结果观察组和对照组治疗后总的有效率分别为86%、61%,差异有统计学意义(P<0.05);治疗后患者NIHSS评分比治疗前降低,ADL和MMSE评分比治疗前升高,差异均有统计学意义(P<0.05),且观察组效果优于对照组;观察组治疗后血清TG、TC、HCY和FIB含量均改善,对照组仅HCY含量有所降低,和治疗前对比差异有统计学意义(P<0.05)。结论栝楼桂枝汤联合针刺对卒中后轻度认知障碍患者疗效显著,可明显改善其认知功能和神经功能,且安全性较好。

Objective To analyze the curative effect of trichobitacin Guizhi soup combined with acupuncture on patients with mild cognitive impairment after stroke.Methods A total of 115 patients with mild cognitive impairment after stroke in our hospital from May 2015 to May 2017 were selected and divided into two groups according to the random number table method.The observation group(58 cases)were treated with trichobitacin Guizhi soup combined with acupuncture,while control group(57 cases)took trichobitacin Guizhi soup.The clinical efficacy,adverse reaction status,MMSE score,NIHSS score,activities of daily living,the change of serum homocysteine(HCY),total cholesterol(TC),fibrinogen(FIB)and triglyceride(TG)and ADL were observed.The Changes of serum homocysteine,cholesterol,fibrinogen and triglyceride were detected.Results After treatment,the total effective rates in the observation group and the control group were 86%and 61%,respectively,with significant difference(P<0.05).After treatment,the NIHSS score decreased and the ADL and MMSE scores were higher than those before treatment(P<0.05),and the effect of the observation group was better than that of the control group.After the treatment,the levels of TG,TC,HCY and FIB in the observation group were all improved,while the HCY content in the control group was lower than that of the control group there was statistical significance(P<0.05).Conclusion Trichobitacin Guizhi soup combined with acupuncture has significant effect onpatients with mild cognitive impairment after stroke which can significantly improve their cognitive function and neurological function,and the safety is better.