血尿灵冲剂治疗气阴两虚型肾性血尿临床观察

Clinical observation of Xue-Niao-Ling granule on renal hematuria with Qi-Yin deficiency type

目的观察血尿灵冲剂治疗气阴两虚型肾性血尿的临床疗效。方法将120例气阴两虚型肾性血尿患者按随机数字表法分为2组。2组均予西医常规治疗。治疗组61例加血尿灵冲剂治疗;对照组59例加血尿安胶囊治疗。2组均治疗12周。比较2组临床疗效、中医证候疗效;观察2组治疗前后中医证候积分变化,尿红细胞计数及免疫功能指标变化,血清肌酐(Cr)、肾小球滤过率(GFR)及24 h尿蛋白定量变化。结果治疗组临床总有效率88.5%,对照组临床总有效率69.5%,治疗组临床疗效优于对照组(P<0.05)。治疗组中医证候总有效率91.8%,对照组中医证候总有效率72.9%,治疗组中医证候疗效优于对照组(P<0.05)。2组治疗后面色少华、倦怠乏力、腰膝痠软、手足心热、口干咽燥、午后潮热中医证候积分均低于本组治疗前(P<0.05);治疗后治疗组倦怠乏力、手足心热、口干咽燥中医证候积分均低于对照组(P<0.05)。治疗组治疗后尿红细胞计数、血免疫球蛋白(Ig)A均较本组治疗前降低(P<0.05),血补体3(C3)升高(P<0.05);对照组治疗后尿红细胞计数较本组治疗前降低(P<0.05),血C3升高(P<0.05)。治疗后治疗组尿红细胞计数、IgA均低于对照组(P<0.05),血C3高于对照组(P<0.05)。2组治疗前后Cr、GFR及24 h尿蛋白定量比较差异均无统计学意义(P>0.05)。结论血尿灵冲剂治疗气阴两虚型肾性血尿疗效确切,其机制可能是通过调节机体免疫机制,改善血尿患者尿红细胞计数,且具有良好的安全性。

Objective To observe the clinical effects of Xue-Niao-Ling granule on renal hematuria with Qi-Yin deficiency type.Methods 120 cases of Qi-Yin deficiency type renal hematuria patients were randomly devided into two groups according to the random number table method.Both groups were treated by conventional western medicine.61 cases in treatment group were treated by Xue-Niao-Ling granule,and 59 cases in control group were treated by Xue-Niao-An capsule.Both groups were treated for 12 weeks.The clinical efficacy and the efficacy of TCM syndromes of two groups were compared,the change of TCM syndrome score,urine red blood cell count and immune function index,serum creatinine(C r),glomerular filtration rate(G F R)and 24-hour urinary protein quantitative changes were observed before and after treatment in two groups,and the adverse reactions and safety of the two groups indicator evaluation were observed.Results The clinical total effective rate was 8 8.5%in treatment group and 6 9.5%in control group.The clinical efficacy in treatment group was superior to that in the control group(P<0.05).The total effective rate of TCM syndromes in the treatment group was 91.8%,and 72.9%in control group.The therapeutic effect of the TCM syndromes in treatment group was superior to that of the control group(P<0.0 5).The TCM syndrome scores of the 2 groups after the treatment were less colorless,tired and fatigued,waist and knees were weak,hands and foot and heart were hot,dry mouth and throat dryness,and afternoon hot flashes were lower than before treatment in each group(P<0.05).After treatment,the scores of TCM syndromes of tired and fatigued,hands and foot and heart were hot,dry mouth and throat dryness were lower in treatment group than in the control group(P<0.05).After treatment,the urine red blood cell count and serum immunoglobulin(I g)A in treatment group were lower than those before treatment(P<0.05),and blood complement C3 was increased(P<0.0 5),The urine red blood cell count after treatment in control group was lower than before treatment(P<0.05),and C3 was increased(P<0.05).After treatment,the urine red blood cell count and IgA were lower in treatment group than in the control group(P<0.05),and C3 was higher than in the control group(P<0.05).There was no significant difference in the quantification of Cr,GFR and 24-hour urinary protein between the two groups before and after treatment(P>0.0 5).Conclusion Xue-Niao-Ling granule for treating hematuria in Qi-Yin deficiency type may improve the urine red blood cell count in patients with renal hematuria by regulating the immune mechanism of the body and have good safety.