地诺前列酮栓和双球囊导管对羊水偏少足月孕妇引产作用的研究

Investigation the Induced Abortion Effects of Application of Dinoprostone or Cervical Dilatation Double-Balloon in Borderline Oligohydramnios Full-Term Pregnancy

目的:研究地诺前列酮栓(欣普贝生)和宫颈扩张双球囊导管对羊水偏少足月孕妇的引产效果。方法:选择2016年10月—2017年9月河南省人民医院收治的羊水偏少[50 mm<羊水指数(AFI)≤80 mm]的足月孕产妇90例,宫颈Bishop评分≤4分。随机分为2组,每组45例,分别使用欣普贝生或双球囊引产(欣普贝生组和双球囊组)。记录2组产妇的促宫颈成熟效果及母婴结局。结果:从引产到分娩时间欣普贝生组比双球囊组短,差异有统计学意义(t=3.204,P=0.003)。2组产妇24 h阴道分娩率和分娩方式比较差异无统计学意义(均P>0.05)。欣普贝生组缩宫素使用率低于双球囊组,差异有统计学意义(46.7%vs.68.9%,χ~2=4.555,P=0.033)。欣普贝生组产妇出现发热、严重恶心呕吐、子宫过度刺激及胎心率异常的发生率高于双球囊组,但差异无统计学意义(均P>0.05)。结论:对于足月羊水偏少孕妇,欣普贝生和阴道放置双球囊导管均可有效促进宫颈成熟。

Objective:To investigate the induced abortion effects of application of dinoprostone or cervical dilatation double-balloon in borderline oligohydramnios full-term pregnancy.Methods:Ninety full-term pregnant women(50 mm<AFI≤80 mm,cervical Bishop score≤4)who delivered in Henan Provincial People′s Hospital were selected as the observation objects.45 patients of observation group were treated with dinoprostone vaginally,the other 45 patients were treated with cervical dilatation double-balloon vaginally.Then the cervical ripening effects and the materal and fetal outcomes of the two groups were compared.Results:The difference of time of induced labor to vaginal delivery was statistically significant in dinoprostone group and double-balloon group(t=3.204,P=0.003),the vaginal delivery rate within 24 h and the way of delivery in both groups had no obvious difference(P>0.05).The rate of oxytocin infusion in dinoprostone group was statistically significant less than that of double-balloon group(46.7%vs.68.9%,χ2=4.555,P=0.033).But dinoprostone group had more complications(fever,severe vomiting or diarrhea,excessive uterine activity,abnormal fetal heart,meconium-staining amniotic fluid),but the differences were not statistically significant.Conclusions:There is no statistically significant difference in the induced abortion effect between dinoprostone and cervical dilatation double-balloon.