易感基因遗传相关性及检测技术在盆腔器官脱垂的研究

Study on Susceptibility Genetic Epidemiology and Detection in Pelvic Organ Prolapse

盆腔器官脱垂(pelvic organ prolapsed,POP)不仅严重影响生活质量,而且会产生严重并发症。随着社会老龄化,POP患者逐渐增多,目前其病因和发病机制尚未明确。目前研究认为POP是一种具有遗传倾向性的多因素疾病,包括环境因素和遗传因素等,其中环境因素包括分娩损伤、绝经、肥胖、吸烟等高危因素,而对于遗传因素及遗传倾向性尚不明确。分析归纳盆底支持结构和细胞外基质成分的合成代谢、分解代谢、基因突变和(或)多态性等因素,同时对相关遗传基因的前沿技术和相关信号通路等分别进行概述。

Pelvic organ prolapsed(POP)not only seriously affects the quality of life,but also causes serious complications.With the aging society,POP patients are gradually increasing,and no consensus exists among researchers regarding its etiology and pathogenesis.Current research suggests that POP is a multifactorial disease with genetic predisposition,including environmental and genetic factors,etc.Environmental factors include high risk factors such as delivery injury,menopause,obesity and smoking,while genetic factors and genetic predisposition are not yet clear.The anabolism,catabolism,gene mutation,and/or polymorphism of pelvic floor support structures and extracellular matrix components were analyzed,and the leading-edge technologies of related genetic genes and related signal pathways were summarized.