自噬介导的肿瘤相关巨噬细胞调控机制的研究进展

Research progress of autophagy-mediated regulation of tumor associated macrophages

肿瘤细胞及各种基质细胞、免疫细胞、细胞因子等构成了复杂的肿瘤微环境。其中,肿瘤相关巨噬细胞(TAMs)是最重要的基质细胞之一,积极参与肿瘤生长、浸润、转移过程。自噬活动不仅在细胞应激反应和维护内环境稳定中起关键作用,还与肿瘤关系密切,涉及肿瘤微环境中TAMs前体细胞的生成及募集、前体细胞向TAMs极化的重要调节步骤。研究自噬介导的TAMs调控机制有利于更全面的认识肿瘤微环境中复杂的调控网络系统,并可能打开肿瘤治疗的新局面。

Tumor cells,and a variety of stromal cells,immune cells and cytokines constitute a complex tumor microenvironment.Among them,tumor-associated macrophages(TAMs)are one of the most important stromal cells in microenvironment and actively participate in tumor growth,invasion and metastasis.Autophagic activity not only plays a key role in the cellular stress response and maintaining the stability of the internal environment,but it also is closely associated with tumor,involving in the generation and recruitment of TAMs precursor cells in the tumor microenvironment and the important regulatory steps of polarization of the precursor cells to TAMs.The study of autophagy-mediated control of TAMs is conducive to a more comprehensive understanding of the tumor micro-environm ent in the complex regulatory network system,and may open a new situation in cancer treatment.