摘要
同源盒(Homeobox,HOX)基因是一类特殊的转录调节因子,不仅在胚胎发育、细胞生长、分化、迁移等生理性调节机制中起到重要作用,近年来的研究发现,HOX基因表达异常也影响着肿瘤的发生发展。本文主要综述了HOX基因与妇科肿瘤的研究进展,并且阐述了HOX基因在癌症治疗中的指导与应用。期待通过总结现有的研究报道,能够指导在HOX基因方向的探索,从而缓解妇科肿瘤患者的病痛。
The homeobox(HOX)gene is a special type of transcriptional regulator that plays an important role in physiological regulation mechanisms such as embryonic development,cell growth,differentiation and migration.Recent studies have found that HOX gene expression is abnormal and affects the occurrence and development of tumor.This review summarizes the progress of HOX gene and gynecologic oncology including cervical cancer,endometrial cancer and ovarian cancer,and the instruction and application of HOX gene in the treatment of cancer.We are making the guiding direction of exploring HOX gene through summarizing the existed research reports in order to alleviate the pain of gynecological cancer patients.
作者
毕琦玲
周立红
韩毅敏
Bl Qiling;ZH0U Uhong;HAN Yimin(Department of Gynaecology,Harbin Medical University Cancer Hospital,Harbin 150081,China;Department of Gynaecology,Altay Region People's Hospital)
出处
《实用肿瘤学杂志》
CAS
2018年第2期140-143,共4页
Practical Oncology Journal
基金
黑龙江省自然科学基金资助(编号:H2016049)
关键词
HOX
宫颈癌
子宫内膜癌
上皮性卵巢癌
HOX
Cervical carcinoma
Endometrial cancer
Epithelial ovarian cancer
