脂联素通过调控骨代谢在骨质疏松症中的研究与进展

Research advances in adiponectin preventing osteoporosis by bone metabolism regulation

背景:脂联素是近年来发现的与肥胖呈负相关的脂肪细胞因子之一,作为一种内源性的生物活性多肽类物质,除研究发现它与胰岛素抵抗、2型糖尿病、代谢综合征等病变的发生密切相关外,它还重要参与骨代谢的调控。目的:叙述脂联素在骨代谢中的作用机制,主要阐述脂联素与成骨及破骨之间的相互内在关系。方法:由第一作者检索2003至2017年Pub Med及CNKI等数据库收录的有关于脂联素在骨代谢方面的实验研究及研究进展。中文检索词分别为:"脂联素、骨质疏松、骨代谢、骨形成、骨吸收",英文检索词分别为:"adiponectin;osteoporosis;bone metabolism;osteogensis;bone absorption",文章主要从脂联素及其受体,骨组织的生理代谢,脂联素分别对骨形成及骨吸收的作用四个方面进行综述。结果与结论:脂联素对骨代谢的影响是一种综合作用的效应,主要是通过自分泌、旁分泌及内分泌影响胰岛素信号通路3种方式发挥作用的,而这3种方式大多是通过OPG/RANKL/RANK轴系统的调控来发挥主要的生物学作用,尤其是在对骨形成和骨吸收方面的作用效应更为重要。脂联素有可能通过调控骨代谢防治骨质疏松症的发生。

BACKGROUND:Adiponectin is one of the adipocytokines that have been found to be negatively correlated with obesity in recent years.As an endogenous bioactive peptide,adiponectin is shown to be associated with insulin resistance,type 2 diabetes mellitus,metabolic syndrome,and participate in the regulation of bone metabolism.OBJECTIVE:To describe the mechanism of adiponectin in bone metabolism,and mainly clarify the correlation of adiponectin with osteoblasts and osteoclasts.METHODS:The first author searched PubMed and CNKI databases for the articles addressing the experimental research and research progress of adiponectin in bone metabolism published from 2003 to 2017.The keywords were“adiponectin,osteoporosis,bone metabolism,osteogensis,bone absorption”in English and Chinese,respectively.Adiponectin,its receptors,bone metabolism,adiponectin effects on bone formation and bone resorption were reviewed.RESULTS AND CONCLUSION:Adiponectin exerts a comprehensive effect on bone metabolism,mainly through autocrine,paracrine and endocrine,insulin signaling pathways.Besides,it exerts biological effects mostly by regulating OPG/RANKL/RANK system,especially in bone formation and bone resorption.Therefore,adiponectin may prevent osteoporosis by regulating bone metabolism.