基于近红外荧光制剂的多模态多功能分子影像技术在肿瘤模型中的应用

Application of multi-modal and multi-functional molecular imaging based on near-infrared fluorescence dye in tumor models

多模态融合的分子影像技术整合了多种分子影像技术的优势,已成为当前分子影像领域研究的热点和发展趋势。新近报道的七甲川菁(heptamethine cyanine)染料是一类具有肿瘤靶向性的近红外荧光(nearinfrared fluorescence,NIRF)制剂。该染料独特的光学特征使其在肿瘤分子影像、靶向治疗和药物传递系统方面具有广阔的应用前景。纳米材料包裹该类染料可用于NIRF/MRI双模成像,标记核素后可实现NIRF/PET双模成像,共轭结合化疗药物后,可实现抗肿瘤药物的靶向传递,多个七甲川菁染料的复合物已被用作多模态成像,成为光热、光动力学和组合治疗肿瘤的新策略。

Multi-modal fusion molecular imaging technology integrates the advantages of a variety of molecular imaging techniques,and has become a hotspot and trend in the field of molecular imaging.Heptamethine cyanine dye is a class of novel near-infrared fluorescence(NIRF)dye with tumor targeting properties.With its unique optical properties,the dye has broad application prospects in tumor molecular imaging,targeted therapy and drug delivery system.Nano-materials containing heptamethine cyanine dye can be used for NIRF/MRI dual-modal imaging.NIRF/PET dual-modal imaging can be achieved after labeling with nuclides.Conjugated with chemotherapy drugs,targeted delivery of anti-tumor drugs can also be achieved.Complexes of multiple heptamethine cyanine dyes have been used for multi-modal imaging as a new strategy for photothermal therapy,photodynamic therapy and combined treatment of tumors.