高效联合抗反转录病毒治疗引发继发性骨质疏松的研究进展

Research progress on highly active anti-retroviral therapy induced secondary osteoporosis

高效联合抗反转录病毒治疗(highly active anti-retroviral therapy,HAART)是艾滋病治疗的主要方法,但也是导致骨质疏松和骨量减少的重要因素之一,目前该治疗方法可能的发病机制尚不明确。其中,核苷类反转录酶抑制剂(nucleotide reverse transcriptase inhibitor,NRTI)和蛋白酶抑制剂(protease inhibitors,PI)在诱发骨质疏松症上具有重要作用。本文就NRTI和PI引发骨质疏松的流行病学、可能的相关机制做一综述。

Highly active anti-retroviral therapy(HAART)is a principal therapy method for AIDS.However,HAART is also one of crucial factors inducing bone mass loss and osteoporosis but its related mechanisms are obscure.Of note,nucleotide reverse transcriptase inhibitor(NRTI)and protease inhibitors(PI)may play key roles in inducing osteoporosis.This review summarizes the research progress in epidemiology and associated mechanisms on osteoporosis induced by NRTI and PI.