109例氨曲南不良反应文献分析

Literature Analysis of 109 Cases of Adverse Drug Reaction Induced by Aztreonam

目的探讨氨曲南所致不良反应的一般规律及其特点,为临床合理用药提供参考。方法检索2000—2017年中国期刊全文数据库(CNKI)、万方数据库以及维普中文科技期刊数据库(VIP)收载的氨曲南所致不良反应的个案文献,并就收集到的109例病例进行统计和分析。结果氨曲南所致的不良反应临床表现复杂多样,主要表现为过敏反应、消化系统反应、关节肌肉反应等。用药0.5 h内更易发生不良反应(占55.96%)。结论临床加强对氨曲南不良反应的监测,促进合理用药,降低不良反应的发生率。

Objective To explore the regularity and characteristics of ADRs induced by aztreonam,and to provide a reference for clinical rational use of drugs.Methods China journal full-text database(CNKI),wangfang database,VIP database were retrieved from 2000 to 2017,and 109 case reports of ADRs induced by aztreonam were analyzed and discussed.Results The most common clinical appearances of ADRs induced by aztreonam were anaphylactic reaction and secondly were digestive system and neuromuscular system reaction.The majority of ADRs occurred within 0.5 hour after injection(55.96%).Conclusion Doctors should pay more attention to the rules and characteristics of ADRs induced by aztreonam,and promote safety of drug use and strengthen the clinical care so as to decrease the occurrence of adverse reactions.