塌陷性肾小球病研究进展

Progress in research of collapsing glomerulopathy

塌陷性肾小球病(CG)之前被视为局灶节段性肾小球硬化(FSGS)的一个亚型。但病理上CG更多表现为足细胞增生和细胞骨架微丝减少直至毛细血管襻塌陷,由此区别于FSGS(足细胞数目减少和细胞外基质积聚而出现节段性或球性肾小球硬化),且在流行病学和临床表现上CG也都明显区别于FSGS,因此现将其定义为一个新的独立性疾病。

Collapsing glomerulopathy(CG)was ever considered a variant of focal segmental glomerulosclerosis(FSGS).However,in morphology,CG is characterized by podocyte proliferation,microfilament decrease,and capillary loop collapsing,which are different from the features of FSGS(such as podocyte number decrease,extracellular matrix accumulation,and segmental or glomerular sclerosis).CG is also significantly distinguished from FSGS both in epidemiology and clinical manifestations,therefore it is now recognized as a new independent disease.