药物过敏筛查对甲巯咪唑初治甲状腺功能亢进症患者所致药疹的预防效果

Preventive effects of drug allergy screening on drug eruption caused by methomilazole in patients with initial hyperthyroidism

目的探讨药物过敏筛查对甲巯咪唑初治甲状腺功能亢进症患者所致药疹的预防效果。方法将158例拟行甲巯咪唑治疗的初诊甲亢患者按1∶1比例分为观察组与对照组,每组79例。观察组应用生物共振技术进行药物过敏筛查,甲巯咪唑过敏原为阴性者才给予甲巯咪唑治疗,对照组确诊为甲亢后直接给予甲巯咪唑治疗。观察两组患者药疹发生率。结果观察组药疹发生率低于对照组(P<0.05)。结论甲巯咪唑初治甲亢患者前应用生物共振技术进行药物过敏筛查可有效降低药疹的发生率。

Objective To explore the preventive effect of drug allergy screening on drug eruption caused by methimazole which applied to the initial treatment of patients with hyperthyroidism.Methods A total of 158 patients with newly diagnosed hyperthyroidism,who were scheduled for methimazole therapy,were divided into observation group and control group based on the ratio of 1∶1,with 79 cases in each group.The observation group received drug allergy screening using bio-resonance technique,and the subjects with methimazole allergen negative were treated with methimazole additionally.The subjects in the control group were treated with methimazole directly after diagnosed as hyperthyroidism.The incidence rate of drug eruption was observed in both groups.Results The incidence rate of drug eruption in the observation group was lower than that in the control group(P<0.05).Conclusion The drug allergy screening with bio-resonance technique used before methimazole therapy can effectively reduce the incidence rate of drug eruption in patients with newly diagnosed hyperthyroid.