N-乙酰半胱氨酸辅助治疗对慢性阻塞性肺疾病急性加重期血清降钙素原及前白蛋白的影响

Effects of N-acetylcysteine as adjuvant therapy on serum procalcitonin and prealbumin in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨N-乙酰半胱氨酸(NAC)辅助治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清降钙素原(PCT)及前白蛋白(PA)的影响。方法将200例AECOPD患者按随机数字表法分为观察组和对照组,每组100例。两组均给予常规治疗,观察组在常规治疗基础上加用NAC辅助治疗。比较两组患者血清PCT、血清PA水平及临床疗效。结果治疗后两组患者血清PCT水平均较治疗前下降,PA水平均较治疗前上升(均P<0.05),且观察组两项指标改善均优于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05)。结论 NAC辅助治疗AECOPD可以改善患者血清PCT及PA水平,提高疗效。

Objective To explore the effects of N-acetylcysteine(NAC)as adjuvant therapy on serum procalcitonin(PCT)and prealbumin(PA)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 200 patients with AECOPD were divided into observation group and control group according to the random number table method,with 100 cases in each group.Both groups received conventional treatment,and the observation group was given NAC as adjuvant therapy on the basis of conventional therapy.The levels of serum PCT and PA and the clinical efficacy were compared between the two groups.Results The level of serum PCT decreased and the PA level increased in both groups after treatment compared to the levels before treatment(all P<0.05),and the improvement of the two indicators in the observation group was superior to that in the control group(P<0.05).The total effective rate in the observation group was higher than that in the control group(P<0.05).Conclusion The adjuvant therapy of NAC can improve the serum levels of PCT and PA and optimize the efficacy in the treatment of patients with AECOPD.