丁苯酞序贯治疗对血管性痴呆认知功能改善的临床观察

Clinical observation on the improvement of Cognitive function of Vascular dementia with Butylphthalide Sequential Therapy

目的观察丁苯酞序贯治疗对血管性痴呆认知功能改善的临床应用效果。方法选择我院2015年10月~2017年10月收治的血管性痴呆患者80例,按照随机数字表法分为对照组(n=40)和观察组(n=40),对照组给予丁苯酞氯化钠注射液2周后不给予特殊治疗,观察组给予丁苯酞氯化钠注射液2周后口服丁苯酞软胶囊3个月,比较两组治疗前后简易精神状态量表(MMSE)、长谷川痴呆量表(HDS)、日常生活能力量表(ADL)评分、血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)水平及不良反应情况。结果观察组治疗后MMSE、HDS显著高于对照组(P<0.05),ADL评分显著低于对照组(P<0.05);观察组治疗后Hcy和CRP水平均显著低于对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论丁苯酞序贯治疗可以明显改善血管性痴呆认知功能。

Objective To observe the clinical application effect of butyphthalide sequential therapy on cognitive function improvement of vascular dementia.Methods From October 2015 to October 2017,80 patients with vascular dementia admitted to our hospital were selected and divided into control group(n=40)and observation group(n=40)according to the random number table.The control group was given butyphthalide sodium chloride injection for 2 weeks,and the observation group was given butyphthalide soft capsule for 3 months after given butyphthalide sodium chloride injection for 2 weeks.Before and after treatment,the scores of Simple mental state scale(MMSE),Kyohko Hasegawa Dementia Scale(HDS),Daily living capacity scale(ADL)score,homocysteine(Hcy),C-reactive protein(CRP)and Adverse reactions were compared between the two groups.Results After treatment,the scores of MMSE,HDS in the observation group were significantly higher than those in the control group(P<0.05)and the ADL score was significantly lower than that in the control group(P<0.05),while the ADL score was significantly lower than that in the control group(P<0.05).After treatment,the levels of Hcy and CRP in the observation group were significantly lower than those in the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butyphthalide sequential treatment can significantly improve the cognitive function of vascular dementia.