枸橼酸钾颗粒预防输尿管狭窄术后长期留置双J管结石形成的效果观察

Observation of the effect of Potassium Citrate Granules on the formation of long-term indwelling double J tube stone after ureteral stricture

目的探析枸橼酸钾颗粒预防上尿路术后长期留置双J管结石形成的效果。方法选取2014年6月~2017年6月我院收治的36例输尿管狭窄的患者为研究对象,所有患者均接受手术治疗,且术后均留置1~2条双J管(美国COOK牌,6F,硅胶材质),留置时间为6~12个月。患者入组后运用抽签的方式进行分组,每组18例。对照组术后不服用药物,观察组患者术后服用枸橼酸钾颗粒2.92g(1小包),每晚一次。对两组的双J管留置情况及结石形成情况进行对比分析。结果两组患者术后双J管的留置时间比较差异无统计学意义(P>0.05);观察组患者的尿垢沉积发生率、管壁结石形成率均明显低于对照组,组间差异有统计学意义;观察组患者的并发症发生率明显低于对照组,组间差异有统计学意义;观察组患者用药期间未出现明显不良反应。结论输尿管狭窄术后长期留置双J管患者,建议术后规律服用枸橼酸钾颗粒,可有效预防双J管尿垢沉积和管壁结石的形成,降低留置双J管后的并发症发生率,且用药安全性高,可作为一种安全有效的药物进一步推广应用。

Objective To investigate the effect of potassium citrate granule on the the formation of long-term indwelling double J tube stone after upper urinary tract operation.Methods Thirty-six patients with ureteral stricture from June 2014 to June 2017 were selected as the study subjects.All patients were treated with surgical treatment,and 1-2 double J tubes(COOK 6F,silica gel material)were placed after operation.The retention time was 6-12 months.The patients were divided into groups by drawing lots,18 cases in each group.The control group did not take drugs after operation,and the patients in the observation group took potassium citrate granule 2.92g(1 capsule),once a night.The two groups of double J tube retention and stone formation were compared and analyzed.Results There was no significant difference in the indwelling time of double J tube between the two groups(P>0.05),the incidence of urinary scale deposition and the formation rate of wall stones in the observation group were significantly lower than those in the control group,and the difference between the two groups was significant.The incidence of complications in the observation group was significantly lower than that in the control group,and there was no significant adverse reaction in the observation group.Conclusion The long-term retention of double J tube in patients with ureteral stenosis suggests that the regular use of Potassium Citrate Granules after operation can effectively prevent the formation of urinary scale deposits and wall stones of double J tubes,reduce the incidence of complications after the double J tube indwelling,and have high safety,which can be used as a safe and effective drug to further promote the application.