高血压临床实践指南方法学质量评价

Methodological Quality Assessment of Clinical Practice Guidelines for Hypertension

目的:评价和分析高血压预防和治疗临床实践指南的方法学质量,为临床实践提供明确的推荐意见。方法:检索Pub Med、EMBASE、Web of Science、the National Guideline Clearinghouse(NGC)、中国知网、万方和CBM等数据库获取高血压预防和治疗指南,采用指南研究与评价Ⅱ(AGREEⅡ)工具来评价临床实践指南的质量。结果:35部指南被纳入(5部中文指南和30部英文指南)。所有领域得分(M±SD)分别为:范围和目的(60±10.6)%,参与人员(52±11.1)%,制定的严谨性(35±11.9)%,表达的明晰性(52±9.1)%,应用性(45±11.6)%,编辑独立性(42±15.4)%。基于循证医学方法的指南所有领域得分均高于非循证医学方法的指南(P<0.05)。结论:基于上述研究结果,今后推荐采用更系统的方法来制定和报告临床实践指南。AGREEⅡ在提高指南质量方面是一个有用的工具。

Objective:To evaluate and analyze the methodological quality of the current hypertension clinical practice guidelines in order to give suggestions for doctors in clinical practice.Methods:A systematic search of relevant literature databases(PubMed,EMBASE,Web of Science,the National Guideline Clearinghouse,CNKI,Wanfang and CBM et al.)was conducted to identify the hypertension clinical practice guidelines.The methodological quality of clinical practice guidelines for hypertension were assessed by AGREEⅡinstrument.Results:A total of 35 guidelines(5 Chinese guidelines,30 English guidelines)for hypertension were finally included.The mean scores of six domains by AGREEⅡinstrument were(60±10.6)%,(52±11.1)%,(35±11.9)%,(52±9.1)%,(45±11.6)%and(42±15.4)%.The methodological quality of clinical practice guidelines based on the methods of evidence-based medicine was higher than the general clinical practice guidelines(P<0.05).Conclusion:Based on the current results,the researchers should adopt more systematic methods to make and report clinical practice guidelines.AGREEⅡinstrument is the best tool for improving the quality of clinical practice guidelines.