盐酸氨基葡萄糖对不同时期骨关节炎患者TNF-α、IL-1β以及PGE-2的影响

Effects of Glucosamine Hydrochloride on TNF-α,IL-1β and PGE-2 in Patients with Osteoarthritis

目的:探究并分析盐酸氨基葡萄糖对不同时期骨关节炎患者肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)以及前列腺素E-2(PGE-2)的影响。方法:选取2015年10月至2016年10月我院收治的150例膝骨关节炎(KOA)患者,按照患者KOA严重程度分为轻度组、中度组以及重度组,每组50例。3组患者均采用口服盐酸氨基葡萄糖进行治疗,4周为一个疗程,连续服用两个疗程。观察并记录各组患者TNF-α、IL-1β、PGE-2水平以及视觉模拟评分(VAS评分),同时统计各组患者疗效。结果:各组患者治疗后IL-1β较治疗前均有改善(P<0.05),且中度组治疗前后差值大于轻度组和重度组(P<0.05),轻度组治疗前后差值大于重度组(P<0.05)。各组患者治疗后TNF-α较治疗前均有改善(P<0.05),且中度组治疗前后差值大于轻度组和重度组(P<0.05),轻度组治疗前后差值大于重度组(P<0.05)。各组患者治疗后PGE-2较治疗前均有改善(P<0.05),且中度组治疗前后差值大于轻度组和重度组(P<0.05),轻度组治疗前后差值大于重度组(P<0.05),差异有统计学意义。经秩和检验,各组患者疗效比较差异有统计学意义(u=5.38,P<0.05),中度组患者总有效率高于轻、重度组(P<0.05),轻度组总有效率高于重度组(P<0.05),差异有统计学意义。结论:盐酸氨基葡萄糖能有效降低膝骨关节炎患者炎症反应,改善TNF-α、IL-1β以及PGE-2水平,并提高KOA患者治疗效果。

Objective:To investigate and analyze the effect of glucosamine hydrochloride on tumor necrosis factor(TNF-α),interleukin-1 beta(IL-1β)and prostaglandin E-2(PGE-2)in patients with osteoarthritis in different stages.Methods:150 patients with knee osteoarthritis(KOA)in our hospital from October 2015 to October 2016 were divided into mild group,moderate group and severe group according to the severity of KOA,and each group had 50 cases.Three groups of patients were treated with oral glucosamine hydrochloride,4 weeks for a course of treatment,continuous treatment of two courses.The TNF-α,IL-1β,PGE-2 and visual analogue scale(VAS score)were observed and recorded in each group.Results:After treatment,the patients′IL-1βwere significantly improved compared with before treatment(P<0.05);and the difference before and after treatment in the moderate group was more than that in the severe group and mild group(P<0.05);the difference before and after treatment in the mild group was more than that in the severe group(P<0.05).After treatment,the patients′TNF-αwere significantly improved compared with before treatment(P<0.05);and the difference before and after treatment in the moderate group was more than that in the severe group and mild group(P<0.05),the difference before and after treatment in the mild group was more than that in the severe group(P<0.05).After treatment,the patients′PGE-2 were significantly improved compared with before treatment(P<0.05);and the difference before and after treatment in the moderate group was more than that in the severe group and mild group(P<0.05);the difference before and after treatment in the mild group was more than that in the severe group(P<0.05),with statistical significance.According to the rank sum test,the curative effect of each group had significant difference(u=5.38,P<0.05);the total efficiency of moderate group was significantly higher than that in mild group and severe group(P<0.05);the total efficiency of mild group was significantly higher than the severe group(P<0.05),with statistical significance.Conclusion:Glucosamine hydrochloride can effectively reduce the inflammatory response in patients with knee osteoarthritis,improve the levels of TNF-α,IL-1βand PGE-2,and improve the therapeutic effect of KOA patients.