血管紧张素Ⅱ1型受体自身抗体致心血管损伤的研究进展

Research advances in the cardiovascular injury effects of angiotensin Ⅱ type 1 receptor autoantibody

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摘要近年来的研究表明,异常的自身免疫应答是导致心血管疾病的重要因素之一。Wallukat等首次观察到先兆子痫患者血清中存在高阳性率、高滴度的血管紧张素受体Ⅱ1型受体(angiotensin Ⅱ type 1 receptor,AT1R)自身抗体(AT1R autoantibody,AT1R-AA),该抗体可通过激活AT1R发挥类激动剂样的作用进而导致心肌和血管损伤,由此参与了多种心血管疾病的发生和发展。本文简要综述了近年来有关AT1R-AA的发现、心血管损伤作用及机制以及今后的临床应用前景的研究进展。

作者刘方杰曹济民闫莉

机构地区中国医学科学院/北京协和医学院医学系中国医学科学院基础医学研究所/北京协和医学院基础学院生理学系中国医学科学院基础医学研究所/北京协和医学院基础学院病理生理学系

出处《生理科学进展》 CAS CSCD 北大核心 2018年第2期105-109,共5页 Progress in Physiological Sciences

基金国家自然科学基金(81470540,8167021355)资助课题

关键词血管紧张素II 1型受体自身抗体心血管损伤

分类号 R54 [医药卫生—心血管疾病]

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共引文献5

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血管紧张素Ⅱ1型受体自身抗体致心血管损伤的研究进展

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