多因素回归分析全关节置换术后华法林使用效果

Multifactor regression analysis of the effect of using warfarin following total joint replacement

目的探讨华法林使用剂量和患者因素对全关节置换术后效果的影响。方法选取250例行全关节置换术患者,手术前后给予华法林治疗以预防静脉血栓形成。多因素回归模型分析患者的情况和华法林使用的情况以及华法林使用的影响因素。结果多因素回归分析结果显示,患者的年龄、体重、华法林每日剂量、最大剂量、累积剂量以及住院时间均显著影响华法林的使用效果;每日剂量多因素回归分析结果显示,华法林每日剂量以及住院时间显著影响使用效果;累积剂量多因素回归模型分析结果显示,华法林最大剂量以及住院时间显著影响华法林使用效果。结论患者的年龄、体重以及华法林每日剂量、最大剂量、住院时间均显著影响华法林的使用效果。

Objective To investigate the influence of warfarin using dose and patient factors on postoperative effect following the total joint replacement.Methods The 250 patients who underwent total joint replacement were treated with warfarin before and after the operation to prevent venous thrombosis,multifactor regression analysis model was used to analyze the general situation and the use situation of warfarin in all patients and the effect factors of warfarin.Results Multivariate regression analysis showed that age,body weight,daily warfarin dose,maximum dose,cumulative dose and hospitalization time significantly affected warfarin use effects;multifactor regression analysis of average daily dose showed that daily use dose of warfarin and hospitalization time significantly affected warfarin use effect;multivariate regression model analysis of cumulative dose showed that maximum warfarin dose and hospitalization time significantly affected warfarin use.Conclusions The patients′age,body weight and daily warfarin dose,the maximum dose,hospitalization time all significantly affect warfarin use.