过氧化物酶体增殖物激活受体调控幼龄反刍动物瘤胃的生酮作用及其机制

Peroxisome Proliferator-Activated Receptors:Regulation in Ketogenesis of Young Ruminants and Its Mechanisms

发育良好的瘤胃对于幼龄反刍动物至关重要,不仅关乎其自身的健康,也与其成年后生产性能的发挥息息相关。对于刚出生的幼龄反刍动物,其瘤胃不具有生酮功能,随日龄的增加,瘤胃形态与功能逐渐发育成熟,逐渐具备了该功能。生酮作用是瘤胃发育成熟的关键因素,β-羟丁酸(BHBA)被认为是瘤胃发育成熟的标志。近十几年来,许多学者针对影响瘤胃生酮作用的因素进行了大量研究,发现过氧化物酶体增殖物激活受体(PPARs)对于瘤胃生酮和上皮细胞增殖十分重要,转录因子PPARs可以影响到生酮作用关键酶3-羟基-3-甲基戊二酰辅酶A合成酶2(HMGCS2)的表达。但目前对于PPARs调控瘤胃生酮作用分子机制的了解仍然十分有限,因此本文针对PPARs调控幼龄反刍动物瘤胃发育的研究进展进行了综述。

A well-developed rumen is critical for young ruminants,not only for the health,but also for the production performance after grow up.There is no ketogenic function in rumen of new born young ruminants,the rumen morphology and function gradually mature with increasing of the days of age,and ketogenic function occurs.Ketogenesis is a key factor in rumen development and maturation,and beta-hydroxybutyric acid(BHBA)is thought to be a mark of rumen development and maturation.Over the past decade,researchers have done a lot of researches on the factors that affect rumen ketogenesis,it has been found that peroxisome proliferator-activated receptors(PPARs)are important for the proliferation of epithelial cells and ketogenesis.The expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase 2(HMGCS2)can be influenced by PPARs.But the current understanding of the mechanism of PPARs regulating ketogenesis remains unclear.This paper reviewed the progress of PPARs regulating rumen development in young ruminants.