摘要
目的:探讨归巢细胞黏附分子(CD44)和性别决定相关基因簇-2(SOX-2)在胃癌组织中的表达及其与临床病理参数的关系。方法:采用免疫组织化学SP法检测60例胃癌组织及30例距癌组织边缘2.5cm以上的癌旁正常胃组织中CD44及SOX-2的表达,统计分析二者相关性及与临床病理参数关系。结果:CD44和SOX-2在胃癌中的表达均显著高于癌旁组织(P<0.01)。CD44与SOX-2的表达呈正相关(r=0.316,P=0.008)。CD44的表达与胃癌的分化程度、浸润深度、淋巴结转移相关(P<0.05),而与性别、年龄无关(P>0.05);SOX-2的表达与胃癌的浸润深度、淋巴结转移相关(P<0.05),而与性别、年龄、分化程度无关(P>0.05)。结论:CD44和SOX-2在胃癌发生、发展过程中发挥一定作用,有望成为判断胃癌预后的生物学指标和治疗靶点。
Objective:To investigate the expression of homing cell adhesion molecule(CD44)and sex determining region Y-box2(SOX-2)in gastric carcinoma tissues and their relationship with clinicopathological parameters.Methods:Immunohistochemical SP method was used to detect the expression of CD44 and SOX-2 in 60 cases of gastric carcinoma and 30 cases of gastric mucosa(distance from tumor edge≥2.5 cm).The relationship between the expression of CD44 and SOX-2 and the clinicopathological parameters was statistically analyzed.Results:The expression of CD44 and SOX-2 in gastric cancer was significantly higher than that in paracancerous tissues(P<0.01).There was a positive correlation between the expresion of CD44 and SOX-2(r=0.316,P=0.008).The expression of CD44 was correlated with the degree of differentiation,depth of invasion and lymph node metastasis(P<0.05),while there was no correlation between sex and age(P>0.05).The expression of SOX-2 in gastric cancer was correlated with the infiltration depth and lymphatic metastasis(P<0.05),while there was no correlation between the degree of differentiation,sex and age(P>0.05).Conclusion:CD44 and SOX-2 play a certain role in the occurrence and development of gastric cancer,and may become biological indicators and therapeutic targets for predicting the prognosis of gastric cancer.
作者
王铮
席可望
张泽健
宫爱梅
李家俊
邓丽英
Wang Zheng;Xi Kewang;Zhang Zejian(Changzhi Medical College)
出处
《长治医学院学报》
2018年第2期85-88,共4页
Journal of Changzhi Medical College
基金
2016年度国家级大学生创新训练计划项目(201610117004)