醒脑静辅助超早期微创手术对基底节区脑出血患者外周血IFN-γ、TIM-3表达的影响

The effect of Xingnaojing injection on the levels of IFN-γand TIM-3 in patients with basal ganglia hemorrhage underwent super early minimally invasive surgery

目的:探讨醒脑静辅助超早期微创手术对基底节区脑出血患者外周血干扰素(IFN-γ)、T细胞免疫球蛋白黏蛋白3(TIM-3)表达的影响。方法:收集2014年8月至2017年5月本院收治的102例基底节区脑出血患者,采用随机数字表法将患者分为观察组与对照组,每组51例。对照组进行常规治疗配合超早期微创手术,观察组则在对照组治疗基础上加用醒脑静注射液辅助治疗。比较两组治疗效果(NIHSS、GCS及FMA评分)、外周血IFN-γ、TIM-3mRNA水平差异。结果:治疗后,两组NIHSS评分、外周血IFN-γ、TIM-3 mRNA水平明显低于治疗前(P<0.05),GCS评分、FMA评分明显高于治疗前(P<0.05);观察组治疗后NIHSS评分、IFN-γ水平、TIM-3mRNA水平明显低于对照组(P<0.05),GCS评分、FMA上肢及下肢评分均明显高于对照组(P<0.05)。结论:醒脑静辅助超早期微创手术具有降低基底节区脑出血患者体内IFN-γ、TIM-3mRNA水平,提高免疫功能,抑制脑部缺血再灌注损伤,恢复神经功能的效果。

Objective:To investigate the effect of Xingnaojing injection on the levels of interferon(IFN)-γand T cell immunoglobulin mucin-3(TIM-3)in patients with basal ganglia hemorrhage who underwent super early minimally invasive surgery.Methods:102 cases of patients with basal ganglia hemorrhage admitted to our hospital from August 2014 to May 2017 were selected and randomly divided into an observation group and a control group,with 51 cases in each group.The patients in the control group received conventional therapy combined with super early minimally invasive surgery,while those in the observation group were treated as the control group with addition of Xingnaojing injection.The NIHSS score,GCS score,FMA score and the levels of IFN-γand TIM-3 between the two groups were compared.Results:After treatment,the NIHSS score and the levels of IFN-γand TIM-3 were decreased,whereas the GCS and FMA scores were increased in both groups(P<0.05).The changes were more obvious in the observation group(P<0.05).Conclusion:Xingnaojing injection application in ultra-minimally invasive surgery could reduce the levels of IFN-γand TIM-3 in patients with basal ganglia hemorrhage.It contributed to the improvement of immune function,inhibition of cerebral ischemia-reperfusion injuries,and the restoration of nerve function.