儿童过敏性紫癜VCAM-1、VEGF及免疫球蛋白的变化及相关性

CHANGES AND CORRELATION OF VCAM-1,VEGF AND IMMUNOGLOBULIN IN CHILDREN ALLERGIC PURPURA

目的:探讨过敏性紫癜患儿外周血血管细胞黏附分子-1、内皮生长因子及免疫球蛋白的含量变化在过敏性紫癜的发病机制中的作用。方法:选取HSP患儿28例、HSPN患儿22例和30例健康儿童为对照组,采用ELISA的方法进行检测各组VCAM-1和VEGF的含量,同时采用全自动生化仪检测各组患儿免疫球蛋白水平。比较HSP组、HSPN组和正常对照组之间VCAM-1、VEGF和免疫球蛋白的差异,并进行相关性分析。结果:血浆VCAM-1和VEGF含量HSPN组>HSP组>正常对照组,差异有统计学意义(P<0.01);HSPN组、HSP组与正常对照组Ig A水平比较,差异有统计学意义(P<0.05)。HSPN组与HSP组Ig A水平比较及各组间Ig M和Ig G水平比较差异无统计学意义(P>0.05)。血浆中VCAM-1和VEGF水平均与Ig A水平呈正相关,VCAM-1和VEGF之间也呈正相关(均r>0,P<0.05)。结论:VCAM-1和VEGF均参与了HSP血管炎的发生过程,同时与肾脏损害的程度密切相关。

Objective:To explore the effect of the changes in the content of endothelial growth factor and immunoglobulin in peripheral blood vascular cells of allergic purpura in the pathogenesis of allergic purpura.Methods:28 cases children with HSP,22 cases of children with HSPN and 30 cases of healthy children as control group,adopt the method of ELISA test groups VCAM-1 and the content of VEGF,at the same time,using automatic biochemical analyzer test groups with immunoglobulin levels.The differences of VCAM-1,VEGF and immunoglobulin between HSP group,HSPN group and normal control group were compared and the correlation analysis was conducted.Results:There were statistically significant differences between the plasma VCAM-1 and VEGF content HSPN grou P>HSP grou P>,and the difference was statistically significant(P<0.01).There was a statistically significant difference between HSPN group and HSP group and the normal control group IgA(P<0.05).There was no statistically significant difference between HSPN group and HSP group IgA level and between the IgM and IgG levels(P>0.05).The levels of VCAM-1 and VEGF in plasma were positively correlated with IgA level,and there was positive correlation between VCAM-1 and VEGF(all r>0,P<0.05).Conclusion:VCAM-1 and VEGF are both involved in HSP vasculitis,and are closely related to the degree of renal damage.