依巴斯汀对慢性自发性荨麻疹患者血清白介素25、33水平影响

The Influences of Ebastine on the Levels of Serum Interleukin-25 and Interleukin-33 in Patients With Chronic Idiopathic Urticaria

目的探讨依巴斯汀对慢性自发性荨麻疹患者血清白介素25、33的影响。方法 50例慢性自发性荨麻疹患者,健康对照20例。慢性自发性荨麻疹患者口服依巴斯汀治疗4周。采用酶联免疫吸附试验(ELISA)检测血清IL-25、IL-33水平,分析依巴斯汀对慢性自发性荨麻疹患者治疗前后IL-25、IL-33水平影响。结果慢性自发性荨麻疹患者IL-25、IL-33水平较健康对照组显著升高(P<0.05),且与患者病情呈正相关(r=0.41,0.48,P<0.05)。慢性自发性荨麻疹患者口服依巴斯汀治疗4周,有效率为74.47%,患者IL-25较治疗前明显降低(P<0.05),与健康对照组相比差异无统计学意义(P>0.05),患者IL-33水平较治疗前明显降低(P<0.05),与健康对照组相比差异无统计学意义(P>0.05)。结论 IL-25、IL-33在慢性自发性荨麻疹患者外周血中表达水平升高,且与病情严重程度呈正相关。

Objective To study the influences of ebastine on the levels of serum interleukin-25 and interleukin-33 in patients with chronic idiopathic urticaria.Methods 50 patients with chronic idiopathic urticaria and 20 healthy people were divided into two groups.Patients were treated with bastine for 4 weeks.The levels of serum IL-25 and IL-33 from both patients and healthy people were measured by ELISA method before and after treatment.Results Compared with healthy people,before the treatment,the levels of serum IL-25、IL-33 were significantly higher in patients with chronic idiopathic urticaria(P<0.05).The concentration of IL-25、IL-33 were positive correlated with the severity of patients’condition.(r=0.41,0.48,P<0.05).The effective rate was 74.47%.After the treatment the levels of serum IL-25 and IL-33 were decrease in patients with chronic idiopathic urticaria(P<0.05),there were no significant difference compared with the healthy people(P>0.05).Conclusion The high expression of IL-25,IL-33 in patients with chronic urticaria were positively correlated with the severity of patients’condition.