胸腔积液脱落细胞学检查与血清、胸腔积液肿瘤标志物水平CEA、CYFRA21-1、CA125相关性探讨

Correlation Between Pleural Effusion Exfoliative Cytology Test and Serum,Pleural Effusion Tumor Marker Level CEA,CYFRA21-1,CA125

目的探讨胸腔积液脱落细胞学检查与血清、胸腔积液中肿瘤标志物水平的相关性。方法选择180例送检标本中54例确诊为恶性肿瘤并发胸腔积液的患者,根据细胞学是否查见恶性细胞,分为两组并对其同时期血清、胸腔积液肿瘤标志物进行检测分析。结果初诊患者检出恶性细胞组血清CEA、CYFRA21-1和CA125水平与胸腔积液比较有显著差异(P<0.01);未检出恶性细胞组血清CEA、CYFRA21-1和CA125水平与胸腔积液比较无显著性差异(P>0.05);检出恶性细胞组胸腔积液CEA、CYFRA21-1和CA125水平与未检出恶性细胞组比较有显著性差异(P<0.01)。结论浆膜腔积液细胞学检查方法简便、快捷、检出率高,注重细胞学检查并联合检测CEA、CYFRA21-1和CA125和T/S比值有助于积液性质的诊断,对提高肿瘤的诊断、分期、治疗起着重要作用。

Objective To investigate the correlation between pleural effusion exfoliative cytology test and the level of tumor markers in serum and pleural effusion.Methods Fifty-four cases of malignant tumors complicated with pleural effusions were examined in 180 cases.According to cytology,malignant cells were detected and divided into two groups.Simultaneously,serum and pleural effusion tumor markers were analyzed.Results The levels of serum CEA,CYFRA21-1 and CA125 in malignant cells of newly diagnosed patients were significantly different from those in pleural effusion(P<0.01).The serum CEA,CYFRA21-1 and CA125 were no significant difference with those in pleural effusion in undetected malignant cell group(P>0.05).The levels of pleural effusion CEA,CYFRA21-1,and CA125 in malignant cells group were significantly different from those in the group without malignant cells(P<0.01).Conclusion The method of cytosolic effusion cytology is simple,rapid and high detection rate.Focus on cytological examination and combined detection of CEA,CYFRA21-1 and CA125 and T/S ratio is helpful to the diagnosis of effusion properties,to improve tumors.The diagnosis,staging,and treatment play an important role.