影响输尿管移行细胞癌患者预后的术前因素

Preoperative prognostic factors of ureteral transitional cell carcinoma

目的评估输尿管移行细胞癌行输尿管肿瘤根治术术前预后相关预测因素。方法收集180例行输尿管肿瘤根治术的输尿管移行细胞癌患者的临床资料并对患者进行随访,评估术前相关预测因素对其预后的影响。结果肾积水程度、肿瘤位置、肿瘤最大长径、贫血、患侧肾功能、白蛋白-球蛋白比值(AGR)、高血小板症等因素与肿瘤的T分期具有相关性。肾积水程度、肿瘤最大长径、贫血、AGR、患侧肾功能、高血小板症等因素与肿瘤的分级具有相关性。存在多因素的高风险分组输尿管移行细胞癌患者的肿瘤预后较差,不同风险组间的预后具有显著的统计学意义(P<0.001)。结论输尿管移行细胞癌患者术前预测因素与肿瘤的T分期、肿瘤的分级具有相关性,并影响患者术后的肿瘤特定生存率(CSS)、无膀胱肿瘤复发生存率(RFS)、无远处转移生存率(MFS)。

Objective To evaluate the preoperative factors which could influence the prognosis of ureteral transitional cell carcinoma(UTCC).Methods A total of 180 UTCC patients treated with radical nephroureterectomy(RNU)were enrolled and followed up.The preoperative prognostic factors were analyzed.Results The degree of hydronephrosis,tumor location,tumor diameter,anemia,renal function of the affected side,A/G,and thrombocythemia were associated with tumor T staging and grading.Patients with multiple high risks showed poor prognosis.Patients with different risks showed different prognosis(P<0.001).Conclusion Preoperative prognostic factors correlate with tumor T staging and grading,and affect the cancer-specific survival(CSS),recurrence-free survival(RFS)and metastasis-free survival(MFS).