多奈哌齐联合高压氧治疗脑损伤患者失语的临床研究

Clinical Study of Donepezil Combined with Hyperbaric Oxygen in the Treatment of Aphasia in Patients with Brain Injury

目的探讨多奈哌齐联合高压氧治疗脑损伤患者失语的临床效果。方法回顾分析该院神经内外科2015年1月—2017年1月之间收治60例脑损伤失语患者的临床资料,随机分为对照组和实验组,对照组30例患者实施常规临床治疗,实验组30例患者实施多奈哌齐联合高压氧治疗,比较两组治疗效果。结果实验组治疗3个疗程后,各项测试结果评分均明显升高,且第1、第2、第3疗程测试评分均明显高于对照组,两组比较差异有统计学意义(P<0.05)。其中实验组患者第一疗程检测结果:失语指数(57.02±14.23)分、命名(4.30±1.72)分、复述(6.42±1.86)分、理解(6.14±2.01)分、流畅性(6.14±1.15)分以及信息量(5.99±1.07)分;第二疗程失语指数(69.41±13.81)分、命名(5.71±1.55)分、复述(7.40±2.10)分、理解(7.62±1.75)分、流畅性(7.62±2.74)分以及信息量(7.04±2.11)分;第三疗程失语指数(81.09±11.53)分、命名(7.46±1.54)分、复述(8.53±1.16)分、理解(8.53±1.97)分、流畅性(8.53±1.23)分以及信息量(7.94±1.84)分。对照组患者第一疗程检测结果:失语指数(52.37±13.24)分、命名(3.93±1.52)分、复述(5.92±1.56)分、理解(5.80±1.42)分、流畅性(4.94±1.47)分以及信息量(5.57±2.01)分;第二疗程失语指数(55.91±14.34)分、命名(4.14±1.44)分、复述(6.13±1.89)分、理解(6.24±2.02)分、流畅性(5.20±2.04)分以及信息量(6.20±1.53)分;第三疗程失语指数(63.93±13.32)分、命名(5.12±1.72)分、复述(7.16±2.05)分、理解(7.06±2.43)分、流畅性(5.83±2.33)分以及信息量(6.73±2.011)分。结论脑损伤失语患者接受多奈哌齐联合高压氧治疗,有助于患者语言功能和非语言功能的恢复,因而临床应用价值较高。

bjective This paper tries to investigate the clinical effect of donepezil combined with hyperbaric oxygen in the treatment of aphasia in patients with brain injury.Methods Retrospective analysis of this hospital neurology and department from January 2015 to January 2017 in this hospital 60 cases of brain injury clinical data of patients with aphasia,were randomly divided into control group and experimental group,30 cases in the control group were given routine clinical treatment,the experimental group of 30 patients with donepezil combined with hyperbaric oxygen therapy,the treatment effects were compared between the two groups.Results After 3 courses of treatment in the experimental group,the scores of the test results were significantly increased,and the scores of the first,second and third courses of treatment were significantly higher than those of the control group,and there was statistical significance between the two groups(P<0.05).The patients in the experimental group the first course of treatment of aphasia index(57.02±14.23)points,name(4.30±1.72)points,(6.42±1.86)points repeat,understanding(6.14±2.01)points,fluency(6.14±1.15)points and the amount of information(5.99±1.07)points;the second refers to the treatment of aphasia the number of(69.41±13.81)points,name(5.71±1.55)points,(7.40±2.10)points repeat,understanding(7.62±1.75)points,fluency(7.62±2.74)points and the amount of information(7.04±2.11)points;the third course of aphasia(81.09±11.53)points index,named(7.46±1.54)points,(8.53±1.16)points,(8.53±1.97)points understanding and fluency(8.53±1.23)points and the amount of information(7.94±1.84)pointspointspointspoints points.Patients in the control group the first course of treatment.Aphasia index(52.37±13.24)points,name(3.93±1.52)points,(5.92±1.56)pointspoints repeat,understanding(5.80±1.42)points,fluency(4.94±1.47)points and the amount of information(5.57±2.01)points;second index(treatment of aphasia(55.91±14.34)points,named(4.14±1.44)points,(6.13±1.89)points repeat,understanding(6.24±2.02)points,fluency(5.20±2.04)points and the amount of information(6.20±1.53)points;the third course of aphasia(63.93±13.32)points index,named(5.12±1.72)points,(7.16±2.05)points repeat,understanding(7.06±2.43)points,fluency(5.83±2.33)points and the amount of information(6.73±2.011)points.Conclusion Donepezil combined with hyperbaric oxygen therapy in patients with aphasia after brain injury is helpful for the recovery of language function and non-verbal function.Therefore,it has high clinical value.