不同停药方式糖皮质激素治疗亚急性甲状腺炎的临床疗效对比分析

Comparison of Clinical Efficacy of Glucocorticoid in the Treatment of Subacute Thyroiditis with Different Ways of Withdrawal

目的研究并分析治疗亚急性甲状腺炎患者时使用不同停药方式糖皮质激素的效果。方法方便选取2015年12月—2016年12月该院收集的亚急性甲状腺炎患者共96例,通过区组随机化分为对照组(48例)和观察组(48例),均接受糖皮质激素治疗,对照组在红细胞沉降率恢复正常后停用糖皮质激素治疗,观察组在治疗2周后逐步减少剂量直到用药结束,将两组临床疗效、停药3个月后亚急性甲状腺炎的复发率和不良反应情况进行观察和对比。结果观察组的总有效率为97.92%,显著高于对照组的77.08%(χ~2=9.524,P=0.002),对照组停药后复发率为14.60%,远高于观察组的0.00%,两组患者对比差异有统计学意义(P<0.05)。观察组不良反应率为16.70%,低于对照组的27.10%,两组患者对比差异有统计学意义(P<0.05)。结论在亚急性甲状腺炎患者的治疗过程中,尽快使用足量的糖皮质激素并逐渐缓慢减量能够显著提升临床疗效,值得推广应用。

Objective This paper tries to study and analyze the effect of different dosage forms of glucocorticoid in patients with subacute thyroiditis.Methods A total of 96 patients with subacute thyroiditis collected from December 2015 to December 2016 were convenient selected and randomly divided into control group(n=48)and observation group(n=48)Corticosteroid treatment,the control group in the erythrocyte sedimentation rate returned to normal after the corticosteroid treatment disabled,the observation group in the treatment after 2 weeks to gradually reduce the dose until the end of medication,the two groups of clinical efficacy,withdrawal 3 months after subacute thyroiditis The recurrence rate and adverse reactions were observed and contrast.Results The total effective rate was 97.92%in the observation group,which was significantly higher than that in the control group 77.08%(χ2=9.524,P=0.002).The relapse rate was 14.60%in the control group,which was much higher than that in the observation group(0.00%),There was significant difference between the two groups(P<0.05).The adverse reaction rate was 16.70%in the observation group and 27.10%in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of subacute thyroiditis patients,the use of sufficient amount of glucocorticoid as soon as possible and gradually slow down the reduction can significantly improve the clinical efficacy,it is worth promoting the application.