选择性β_1-受体阻滞剂治疗慢阻肺患者的荟萃分析

A Meta-analysis of Selective β_1-receptor Blockers in Patients with Chronic Obstructive Pulmonary Disease

目的对选择性β_1-受体阻滞剂治疗慢阻肺患者的荟萃进行分析,通过多层次的观察达到相应的预防治疗的效果。方法方便选择2016年1月—2017年10月该院内科住院治疗的88例AECOPD合并CHF患者作为研究对象。将AECOPD合并CHF患者随机分为对照组和观察组,对照组采用常规治疗,观察组在常规治疗的基础上加用富马酸比索洛尔,治疗开始前和治疗后第11天采血检测BNP和蛋白定量值的分析。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);与治疗前相比,治疗后两组患者的BNP均明显下降,差异有统计学意义(P<0.05),观察组BNP下降更明显,与对照组比较,差异有统计学意义(P<0.05);两组治疗后PaO_2和PaCO_2均得到改善,差异有统计学意义(P<0.05),但两组治疗后改善幅度比较,差异无统计学意义(P>0.05)。结论在选择性β_1-受体阻滞剂的过程中,对β_1-受体的亲和力比对β_2-受体强11~34倍,需要对β_1-受体阻滞剂的优点进行全面性的发挥,并在各种层面的对照组的分析中使得整体的受体阻滞剂治疗效果更加显著。

Objective To analyze the meta-analysis of selective beta 1-blockers in the treatment of chronic obstructive pulmonary disease,and to achieve the corresponding preventive and therapeutic effects through multi-level observation.Methods 88 cases of AECOPD combined with CHF were convenient selected from January 2016 to October 2017 in our hospital.AECOPD patients with CHF were randomly divided into control group and observation group,control group with conventional treatment,the observation group in the conventional treatment plus bisoprolol,analysis of eleventh samples were measured BNP and protein values before treatment and after treatment.Results The observation group the total efficiency is higher than the control group,the difference was statistically significant(P<0.05);compared with before treatment,after treatment two groups of patients with BNP were significantly decreased,the difference was statistically significant(P<0.05),the observation group BNP decreased more significantly,compared with the control group,the difference with Statistical significance(P<0.05);PaO2 and PaCO2 were improved after treatment in the two groups.CME ninth,twenty-first,175 before treatment,the difference was statistically significant(P<0.05),but there was no significant difference in the improvement rate between the two groups after treatment(P>0.05).Concludion In the selectiveβ1-blockers,the affinity ofβ1-receptors is 11 to 34 times stronger than that ofβ2-receptors,and it is necessary to comprehensively evaluate the advantages ofβ1-blockers.Play,and in a variety of levels of control group analysis makes the overall effect of receptor blocker treatment more significant.