丙泊酚联合瑞芬太尼靶控输注对老年患者髋关节置换术后认知功能的影响

Study on the effect of propofol combined with remifentanil target-controlled infusion on cognitive function in elderly patients after hip replacement

目的:分析、研讨丙泊酚联合瑞芬太尼靶控输注对老年患者髋关节置换术后认知功能的影响。方法:收治老年髋关节置换术患者80例,平分两组。对照组接受七氟醚联合芬太尼麻醉,研究组接受丙泊酚联合瑞芬太尼靶控输注麻醉,观察、记录其认知功能、拔管时间、苏醒时间等,并比较。结果:研究组认知功能障碍发生率7.50%,低于对照组的20%(P<0.05)。研究组苏醒时间、恢复自主呼吸时间、拔管时间均少于对照组(P<0.05)。对比MMSE评分,术后3 h、6 h时研究组高于对照组(P<0.05)。结论:建议给予老年髋关节置换术患者丙泊酚联合瑞芬太尼靶控输注麻醉,能缩短术后清醒时间,认知功能障碍发生可能性得到降低。

Objective:To analyze and discuss the effect of propofol combined with remifentanil on the cognitive function of the elderly patients after hip replacement.Methods:80 elderly patients with hip replacement were selected.They were divided into the two groups on average.The control group received sevoflurane combined with fentanyl anesthesia.The study group received propofol plus remifentanil target controlled infusion anesthesia.The cognitive function,extubation time,and awakening time were observed and compared.Results:The incidence of cognitive function in the study group was 7.50%lower than that of the control group(20%)(P<0.05).The time of recovery,the time of spontaneous breathing and the time of extubation of the study group were all lower than that of the control group(P<0.05).Compared with the MMSE score,the study group was higher than the control group at 3 h and 6 h after operation(P<0.05).Conclusion:After analysis,propofol and remifentanil target controlled infusion anesthesia is recommended for elderly patients undergoing hip arthroplasty,which can shorten postoperative wakefulness time and reduce the possibility of cognitive dysfunction.