铋剂四联及传统三联疗法治疗幽门螺杆菌阳性小儿胃炎临床对比研究

Comparative study of bismuth quadruple and traditional triple therapy in the treatment of Helicobacter pylori positive infantile gastritis

目的:比较铋剂四联及传统三联疗法治疗幽门螺杆菌(Hp)阳性小儿胃炎临床效果。方法:收治小儿胃炎患者84例,分别采用传统三联法(三联组)及铋剂四联治疗法(四联组)进行治疗,比较其治疗效果及不良反应情况。结果:四联组治疗总有效率90.48%,Hp清除成功率88.10%,均显著高于三联组(P<0.05)。结论:采用铋剂四联治疗Hp阳性小儿胃炎患者,与常规方案相比,治疗效果更为显著,能够更有效地改善症状,安全、可行。

Objective:To compare the clinical effect of bismuth quadruple and traditional triple therapy in the treatment of Helicobacter pylori positive infantile gastritis.Methods:84 patients with infantile gastritis were treated with the traditional triad(the triple group)and the quadruple therapy(the quadruple group)with bismuth.We compared the therapeutic effects and adverse reactions.Results:The effective rate of the quadruple group was 90.48%,and the successful rate of H.pylori clearance was 88.10%,which was significantly higher than that of the triad group(P<0.05).Conclusion:The treatment of H.pylori(+)children gastritis with bismuth quadruple is more effective than conventional regimen,which is more effective in improving the symptoms of patients,and is safe and feasible.